Abstract
In rabbits the anticonvulsive effect of diacetone alcohol given by mouth is definite. A considerably larger amount of it is required than is required of phenobarbital to produce a similar effect. The latter, however, is much more toxic in larger doses, and causes considerably more irritability to sensory stimuli. The anticonvulsive properties of diacetone alcohol depend on the acetone portion of the molecule. β-hydroxybutyric acid, in itself, is not anticonvulsive.
Footnotes
- Received October 10, 1931.
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