Abstract
1. The coriamyrtin of Merck appears to be somewhat different from and is probably more powerful pharmacologically than that isolated by Riban.
2. The minimum lethal dose for rabbits is 1 mg. per kilogram body weight.
3. It is quickly eliminated from or destroyed in the body of the rabbit and appears to give rise to no cumulative effects.
4. After minimal doses it causes symptoms of stimulation of the respiratory, vaso-motor and cardio-inhibitory centers in the medulla. These symptoms, however, are not observed, or to only a slight extent, in deeply anaesthetised animals.
5. After large doses it induces convulsions having their origin mainly in the brain, but the excitability of the spinal cord is also increased.
6. Coriamyrtin acts more quickly than tutin.
Footnotes
- Received October 23, 1912.
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