Abstract
1. Xysmalobinum, a crystalline glucoside isolated from the root of xysmalobium undulatum, R.Br.,2 is toxic and produces a digitalis-like action on the heart. The degree of toxicity is low compared with other glucosides of similar action, and is less than that of a dry alcoholic extract of the root.
2. The glucoside contracts the smooth muscle of the uterus, intestine, bladder and bronchi, the effect being especially marked in the bronchi. This last results in severe respiratory embarrassment which plays a part in the toxic action. The point of action in smooth muscle is peripheral to the nervous mechanism.
3. The glucoside stimulates the secretion of saliva by stimulation of the terminations of the secretory nerves.
4. A marked diuresis occurs in the rabbit.
Footnotes
- Received October 21, 1929.
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