Research ArticleInflammation, Immunopharmacology, and Asthma
Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance
Mina Youssef, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Marian Hajduch, Anna K. Naumova and Danuta Radzioch
Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 476-487; DOI: https://doi.org/10.1124/jpet.119.263715
Mina Youssef
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Juan B. De Sanctis
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Juhi Shah
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Daciana Catalina Dumut
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Marian Hajduch
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Anna K. Naumova
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
Danuta Radzioch
Department of Human Genetics (M.Y., A.K.N., D.R.), Department of Pharmacology and Therapeutics (J.S.), Division of Experimental Medicine, Department of Medicine (D.C.D., D.R.), and Department of Obstetrics and Gynecology (A.K.N.), McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada (M.Y., J.S., D.C.D., D.R.); and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic (J.B.D.S., M.H., D.R.)
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Research ArticleInflammation, Immunopharmacology, and Asthma
LAU-7b Efficacy in Asthmatic Zpbp2 KO and WT A/J Mice
Mina Youssef, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Marian Hajduch, Anna K. Naumova and Danuta Radzioch
Journal of Pharmacology and Experimental Therapeutics June 1, 2020, 373 (3) 476-487; DOI: https://doi.org/10.1124/jpet.119.263715
Research ArticleInflammation, Immunopharmacology, and Asthma
LAU-7b Efficacy in Asthmatic Zpbp2 KO and WT A/J Mice
Mina Youssef, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Marian Hajduch, Anna K. Naumova and Danuta Radzioch
Journal of Pharmacology and Experimental Therapeutics June 1, 2020, 373 (3) 476-487; DOI: https://doi.org/10.1124/jpet.119.263715
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