Research ArticleDrug Discovery and Translational Medicine
Open Access
The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents
Holger Rosenbrock, Riccardo Giovannini, Gerhard Schänzle, Eliza Koros, Frank Runge, Holger Fuchs, Anelise Marti, Klaus G. Reymann, Ulrich H. Schröder, Ernesto Fedele and Cornelia Dorner-Ciossek
Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 633-641; DOI: https://doi.org/10.1124/jpet.119.260059
Holger Rosenbrock
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Riccardo Giovannini
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Gerhard Schänzle
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Eliza Koros
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Frank Runge
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Holger Fuchs
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Anelise Marti
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Klaus G. Reymann
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Ulrich H. Schröder
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Ernesto Fedele
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
Cornelia Dorner-Ciossek
Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.); and Department of Pharmacy, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy (E.F.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
In Vitro and In Vivo Characterization of BI 409306
Holger Rosenbrock, Riccardo Giovannini, Gerhard Schänzle, Eliza Koros, Frank Runge, Holger Fuchs, Anelise Marti, Klaus G. Reymann, Ulrich H. Schröder, Ernesto Fedele and Cornelia Dorner-Ciossek
Journal of Pharmacology and Experimental Therapeutics December 1, 2019, 371 (3) 633-641; DOI: https://doi.org/10.1124/jpet.119.260059
Research ArticleDrug Discovery and Translational Medicine
In Vitro and In Vivo Characterization of BI 409306
Holger Rosenbrock, Riccardo Giovannini, Gerhard Schänzle, Eliza Koros, Frank Runge, Holger Fuchs, Anelise Marti, Klaus G. Reymann, Ulrich H. Schröder, Ernesto Fedele and Cornelia Dorner-Ciossek
Journal of Pharmacology and Experimental Therapeutics December 1, 2019, 371 (3) 633-641; DOI: https://doi.org/10.1124/jpet.119.260059
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