| mg/kg | |
Morphine alone | 7.52 ± 0.80 | |
Morphine after 1 mg/kg MCAM | | |
1 day | 17.14 ± 2.20 | 2.38 (1.65, 3.08)a |
5 days | 7.95 ± 0.53 | 1.14 (0.85, 1.41) |
Morphine alone | 7.52 ± 0.80 | |
Morphine after 3.2 mg/kg MCAM | | |
1 day | 68.61 ± 8.95 | 10.21 (5.77, 14.29)a |
5 days | 29.27 ± 0.55 | 4.47 (2.90, 5.79)a |
9 days | 27.38 ± 1.58 | 4.15 (2.67, 5.39)a |
13 days | 17.38 ± 2.73 | 2.66 (1.28, 3.85)a |
17 days | 8.80 ± 0.14 | 1.33 (0.90, 1.69) |
Morphine alone | 7.30 ± 0.56 | |
Morphine after 10 mg/kg MCAM | | |
1 day | 187.68 ± 7.56 | 26.76 (21.44, 31.81)a |
5 days | 61.68 ± 6.01 | 8.97 (6.01, 11.65)a |
9 days | 41.75 ± 3.90 | 6.11 (3.94, 8.10)a |
13 days | 91.67 ± 10.56 | 12.65 (9.54, 15.59)a |
17 days | 98.95 ± 2.71 | 14.13 (11.36, 16.78)a |
21 days | 100.23 ± 3.90 | 14.23 (11.60, 16.77)a |
29 days | 64.75 ± 8.59 | 9.29 (5.71, 12.39)a |
37 days | 55.06 ± 9.72 | 7.58 (4.63, 10.15)a |
45 days | 35.40 ± 3.06 | 4.95 (4.05, 5.81)a |
53 days | 29.77 ± 0.59 | 4.25 (3.44, 5.02)a |
69 days | 25.73 ± 3.20 | 3.83 (2.02, 5.53)a |