Research ArticleDrug Discovery and Translational Medicine
Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors
Pamela J. Farrell, Christopher J. Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, James Bilakovics, Andrea Fanjul, Jennifer Matuszkiewicz, Artur Plonowski, Paul Rolzin, Urmi Banerjee, Jacques Ermolieff, Zacharia S. Cheruvallath, Christopher McBride, Darian Bartkowski, Crystal Mazur, Alok Pachori and Christopher J. Larson
Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028
Pamela J. Farrell
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Christopher J. Zopf
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Huey-Jing Huang
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Deepika Balakrishna
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Corine Holub
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
James Bilakovics
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Andrea Fanjul
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Jennifer Matuszkiewicz
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Artur Plonowski
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Paul Rolzin
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Urmi Banerjee
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Jacques Ermolieff
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Zacharia S. Cheruvallath
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Christopher McBride
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Darian Bartkowski
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Crystal Mazur
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Alok Pachori
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
Christopher J. Larson
Biological Sciences (P.J.F., H.-J.H., De.B., C.H., J.B., A.F., J.M., A.Pl., P.R., U.B., J.E., C.J.L.), Chemistry (Z.S.C., C.Mc.), and Drug Metabolism and Pharmacokinetics (Da.B.), Takeda California, San Diego, California; Modeling and Simulation, Takeda Boston, Cambridge, Massachusetts (C.J.Z.); and Translational Research Institute for Metabolism and Diabetes, Florida Hospital Campus, Orlando, Florida (C.Ma., A.Pa.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
MetAP2 Inhibitor Translational Pharmacology
Pamela J. Farrell, Christopher J. Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, James Bilakovics, Andrea Fanjul, Jennifer Matuszkiewicz, Artur Plonowski, Paul Rolzin, Urmi Banerjee, Jacques Ermolieff, Zacharia S. Cheruvallath, Christopher McBride, Darian Bartkowski, Crystal Mazur, Alok Pachori and Christopher J. Larson
Journal of Pharmacology and Experimental Therapeutics November 1, 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028
Research ArticleDrug Discovery and Translational Medicine
MetAP2 Inhibitor Translational Pharmacology
Pamela J. Farrell, Christopher J. Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, James Bilakovics, Andrea Fanjul, Jennifer Matuszkiewicz, Artur Plonowski, Paul Rolzin, Urmi Banerjee, Jacques Ermolieff, Zacharia S. Cheruvallath, Christopher McBride, Darian Bartkowski, Crystal Mazur, Alok Pachori and Christopher J. Larson
Journal of Pharmacology and Experimental Therapeutics November 1, 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028
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