Research ArticleNeuropharmacology
Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators
Clare Stokes, Sumanta Garai, Abhijit R. Kulkarni, Lucas N. Cantwell, Colleen M. Noviello, Ryan E. Hibbs, Nicole A. Horenstein, Khalil A. Abboud, Ganesh A. Thakur and Roger L. Papke
Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 252-268; DOI: https://doi.org/10.1124/jpet.119.259499
Clare Stokes
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Sumanta Garai
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Abhijit R. Kulkarni
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Lucas N. Cantwell
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Colleen M. Noviello
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Ryan E. Hibbs
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Nicole A. Horenstein
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Khalil A. Abboud
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Ganesh A. Thakur
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
Roger L. Papke
Departments of Pharmacology and Therapeutics (C.S., R.L.P.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., A.R.K., L.N.C., G.A.T.); and Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas (C.M.N., R.E.H.)
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Research ArticleNeuropharmacology
Mutant Heteromeric nAChRs Sensitive to α7 PAMs
Clare Stokes, Sumanta Garai, Abhijit R. Kulkarni, Lucas N. Cantwell, Colleen M. Noviello, Ryan E. Hibbs, Nicole A. Horenstein, Khalil A. Abboud, Ganesh A. Thakur and Roger L. Papke
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 252-268; DOI: https://doi.org/10.1124/jpet.119.259499
Research ArticleNeuropharmacology
Mutant Heteromeric nAChRs Sensitive to α7 PAMs
Clare Stokes, Sumanta Garai, Abhijit R. Kulkarni, Lucas N. Cantwell, Colleen M. Noviello, Ryan E. Hibbs, Nicole A. Horenstein, Khalil A. Abboud, Ganesh A. Thakur and Roger L. Papke
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 252-268; DOI: https://doi.org/10.1124/jpet.119.259499
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