Abstract
Tetiothalein sodium has a decided bacteriostatic action for Staphylococous albus and for the various forms of streptococci usually associated with infections of human beings. It has, however, only slight action on Gram-negative bacilli of the colon-typhoid group. It kills the various Gram-positive cocci in dilutions of 1:1000 in fifty-five hours and in dilutions of 1:20 in ten minutes.
Although tetiothalein sodium has not as high a phenol coefficient as is desirable, nevertheless, it is definitely germicidal, especially in the higher concentrations, and it may have therapeutics value in certain types of cholecystitis. Preliminary experiments in rabbits seem to indicate that if tetiothalein sodium is given in doses proportionate to the diagnostic dosage for human beings, it may inhibit the localization of infection in the gallbladder.
The experimental results obtained so far were considered worthy of reporting in the hope that they might stimulate further investigation. In this way, some similar dye might be developed which would perhaps have all the essential desirable properties of tetiothalein sodium and still be more germicidal and consequently of more therapeutic value.
Footnotes
- Received July 6, 1929.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|