Abstract
When the adrenal glands were tied off in cats morphine sulphate in various doses had little or no effect upon the rate of the denervated heart.
In eight experiments, with the adrenals intact, morphine sulphate caused marked and sustained increases in the rate of the denervated heart. In six experiments the results were negative.
Reasons are given for believing that the increases in heart rate were caused by the increased secretion of adrenin from the adrenal glands. No explanation can be given for the failure of the heart rate to increase in the six negative experiments.
Footnotes
- Received May 22, 1929.
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