Abstract
Isolated frog sartorius which has been exposed to fairly low tensions of narcotic for some time and then allowed to recover, is less easily narcotized than fresh muscle, the decreased susceptibility being shown in (a) increased period of exposure to narcotic before failure of response to submaximal break shock; (b) failure of normally narcotic tensions to produce narcosis, i.e., to raise the threshold of contraction to at least twice the original threshold; or (c) a threshold-rise in narcosis which is much lower than that observed in normal muscle. These changes are produced by ether, nitrous oxide and acetylene, and are not specific for the individual narcotics. They are ascribed to a physico-chemical or colloidal change in the muscle, possibly brought about by the increase of lactic acid in the muscle under the influence of the narcotic.
Footnotes
- Received March 11, 1928.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|