Abstract
1. The first injection of morphine sulphate made intravenously in dogs with Thiry-Vella fistulas causes an increase in the tonus of the ileum. (Confirmation of Plant and Miller.)
2. Repeated injections of morphine intravenously lead to decrease in general tonus of the intestine and in some instances increased force of the rhythmical contractions.
3. Pilocarpine and morphine have a summating effect upon intestinal tonus.
4. The reaction of the intestine to morphine is not dependent upon the original state of tone of the intestine.
5. Papaverine hydrochloride injected intravenously usually causes a decrease in the general tone of the intestine but in some cases it is apparently also capable of initiating tonus waves.
6. Papaverine in some cases abolishes the action of morphine.
7. Atropine and papaverine and pituitary extract and papaverine have a summating effect upon intestinal tonus, i.e., an intestine relaxed by atropine or by pituitary extract relaxes further with a subsequent injection of papaverine.
8. Blood pressure changes as a result of the injection of the drugs play no apparent rôle in the results obtained upon the intestinal movements and tonus.
9. Pantopon, narceine morphine meconate, narceine hydrochloride and thebaine hydrochloride in the limited number of experiments performed increased the general tonus of the ileum.
Footnotes
- Received April 29, 1929.
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