In the above article [Liu H, Chen Y, Huang L, Sun X, Fu T, Wu S, Zhu X, Zhen W, Liu J, Lu G, Cai W, Yang T, Zhang W, Yu X, Wan Z, Wang J, Summerfield SG, Dong K, and Terstappen GC (2018) J Pharmacol Exp Ther 365(2): 336-345; DOI: https://doi.org/10.1124/jpet.117.245613], subscripts in the middle stacked fraction of eq. (4) and some text below this equation are incorrect. The corrected equation and text are provided below.(4)where the Kp,uu, Kp, fu,tissue, and fu,bl are the mean values of tissue-to-blood unbound concentration ratio, tissue-to-blood concentration ratio, unbound fraction in tissue homogenate, and blood unbound fraction, respectively; the S.D.Kp, S.D.fu,tissue, and S.D.fu,bl are the standard deviation of Kp, fu,tissue, and fu,bl, respectively.
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