Research ArticleMetabolism, Transport, and Pharmacogenomics
Drug Distribution into Peripheral Nerve
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong and Georg C. Terstappen
Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 336-345; DOI: https://doi.org/10.1124/jpet.117.245613
Houfu Liu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Yan Chen
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Liang Huang
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Xueying Sun
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Tingting Fu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Shengqian Wu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Xiaoyan Zhu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Wei Zhen
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Jihong Liu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Gang Lu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Wei Cai
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Ting Yang
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Wandong Zhang
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Xiaohong Yu
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Zehong Wan
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Jianfei Wang
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Scott G. Summerfield
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Kelly Dong
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Georg C. Terstappen
Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
Article Information
vol. 365 no. 2 336-345
PubMed
Print ISSN
Online ISSN
History
- Received October 10, 2017
- Accepted March 1, 2018
- Published online April 3, 2018.
Article Versions
- Earlier version (March 6, 2018 - 06:11).
- You are viewing the most recent version of this article.
Copyright & Usage
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Houfu Liu,
- Yan Chen,
- Liang Huang,
- Xueying Sun,
- Tingting Fu,
- Shengqian Wu,
- Xiaoyan Zhu,
- Wei Zhen,
- Jihong Liu,
- Gang Lu,
- Wei Cai,
- Ting Yang,
- Wandong Zhang,
- Xiaohong Yu,
- Zehong Wan,
- Jianfei Wang,
- Scott G. Summerfield,
- Kelly Dong, and
- Georg C. Terstappen
- Department of Mechanistic Safety and Disposition (H.L., X.S., T.F., S.W.), Bioanalysis, Immunogenicity and Biomarkers (L.H., X.Z., K.D.), Integrated Biological Platform Sciences (Y.C., We.Z., J.L., J.W.), Brain Delivery Technologies (Wa.Z.), Platform Technology and Science (G.C.T.), and Department of Neuroexcitation Discovery Performance Unit (G.L., W.C., T.Y., X.Y., Z.W.), GlaxoSmithKline R&D, Shanghai, People’s Republic of China; and Department of Bioanalysis, Immunogenicity and Biomarkers, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (S.G.S.)
- Address correspondence to:
Dr. Houfu Liu, GlaxoSmithKline R&D China, 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China. E-mail: liuhoufu79{at}hotmail.com
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Research ArticleMetabolism, Transport, and Pharmacogenomics
Drug Distribution into Peripheral Nerve
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong and Georg C. Terstappen
Journal of Pharmacology and Experimental Therapeutics May 1, 2018, 365 (2) 336-345; DOI: https://doi.org/10.1124/jpet.117.245613
Research ArticleMetabolism, Transport, and Pharmacogenomics
Drug Distribution into Peripheral Nerve
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong and Georg C. Terstappen
Journal of Pharmacology and Experimental Therapeutics May 1, 2018, 365 (2) 336-345; DOI: https://doi.org/10.1124/jpet.117.245613
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