Research ArticleMinireviews
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers
Natalie A. Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G. McLaren, Thomas P. Roddy, Douglas G. Johns, Denise Milot, Takhar Kasumov, Mark D. Erion, David E. Kelley and Stephen F. Previs
Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 80-91; DOI: https://doi.org/10.1124/jpet.117.241091
Natalie A. Daurio
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Sheng-Ping Wang
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Ying Chen
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Haihong Zhou
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
David G. McLaren
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Thomas P. Roddy
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Douglas G. Johns
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Denise Milot
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Takhar Kasumov
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Mark D. Erion
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
David E. Kelley
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
Stephen F. Previs
Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)
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In this issue
Research ArticleMinireviews
Supporting Pharmacodynamics Studies via Tracer Kinetics
Natalie A. Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G. McLaren, Thomas P. Roddy, Douglas G. Johns, Denise Milot, Takhar Kasumov, Mark D. Erion, David E. Kelley and Stephen F. Previs
Journal of Pharmacology and Experimental Therapeutics October 1, 2017, 363 (1) 80-91; DOI: https://doi.org/10.1124/jpet.117.241091
Research ArticleMinireviews
Supporting Pharmacodynamics Studies via Tracer Kinetics
Natalie A. Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G. McLaren, Thomas P. Roddy, Douglas G. Johns, Denise Milot, Takhar Kasumov, Mark D. Erion, David E. Kelley and Stephen F. Previs
Journal of Pharmacology and Experimental Therapeutics October 1, 2017, 363 (1) 80-91; DOI: https://doi.org/10.1124/jpet.117.241091
Jump to section
- Article
- Abstract
- Why Are Measurements of Metabolic Flux Important in Drug Discovery?
- Basic Definitions and Principles Surrounding Tracer-Based Studies of Metabolic Flux
- Applying the Definitions and Concepts to a Hypothetical Metabolic Problem
- Studying Metabolic Flux In Vivo: Measurements of Water Turnover
- Using Tracer Studies to Make a Sound Interpretation of Physiologic Regulation
- Summary and Final Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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