Research ArticleNeuropharmacology
Open Access
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman and Rudolph E. Tanzi
Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 31-44; DOI: https://doi.org/10.1124/jpet.117.240861
Steven L. Wagner
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Kevin D. Rynearson
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Steven K. Duddy
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Can Zhang
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Phuong D. Nguyen
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Ann Becker
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Uyen Vo
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Deborah Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Louise Monte
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Justin B. Klee
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Corinne M. Echmalian
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Weiming Xia
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Luisa Quinti
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Graham Johnson
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Jiunn H. Lin
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Doo Y. Kim
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
William C. Mobley
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Robert A. Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
Rudolph E. Tanzi
Department of Neurosciences, University of California, San Diego, La Jolla, California (S.L.W., K.D.R., P.D.N., A.B., U.V., D.M., L.M., W.C.M., R.A.R.); Integrated Nonclinical Development Solutions, Ann Arbor, Michigan (S.K.D.); NuPharmAdvise, Sanbornton, New Hampshire (G.J.); Biopharm Consulting Partners, Ambler, Pennsylvania (J.H.L.); and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts (C.Z., J.B.K., C.M.E., W.X., L.Q., D.Y.K., R.E.T.)
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In this issue
Research ArticleNeuropharmacology
Pharmacological and Toxicological Properties of BPN-15606
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman and Rudolph E. Tanzi
Journal of Pharmacology and Experimental Therapeutics July 1, 2017, 362 (1) 31-44; DOI: https://doi.org/10.1124/jpet.117.240861
Research ArticleNeuropharmacology
Pharmacological and Toxicological Properties of BPN-15606
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman and Rudolph E. Tanzi
Journal of Pharmacology and Experimental Therapeutics July 1, 2017, 362 (1) 31-44; DOI: https://doi.org/10.1124/jpet.117.240861
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