Research ArticleDrug Discovery and Translational Medicine
Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis
Carlos Antonio Trindade-da-Silva, Ahmed Bettaieb, Marcelo Henrique Napimoga, Kin Sing Stephen Lee, Bora Inceoglu, Carlos Ueira-Vieira, Donald Bruun, Sumanta Kumar Goswami, Fawaz G. Haj and Bruce D. Hammock
Journal of Pharmacology and Experimental Therapeutics June 2017, 361 (3) 408-416; DOI: https://doi.org/10.1124/jpet.116.238113
Carlos Antonio Trindade-da-Silva
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Ahmed Bettaieb
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Marcelo Henrique Napimoga
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Kin Sing Stephen Lee
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Bora Inceoglu
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Carlos Ueira-Vieira
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Donald Bruun
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Sumanta Kumar Goswami
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Fawaz G. Haj
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
Bruce D. Hammock
Department of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Inhibition of sEH Blocks Alveolar Bone Loss
Carlos Antonio Trindade-da-Silva, Ahmed Bettaieb, Marcelo Henrique Napimoga, Kin Sing Stephen Lee, Bora Inceoglu, Carlos Ueira-Vieira, Donald Bruun, Sumanta Kumar Goswami, Fawaz G. Haj and Bruce D. Hammock
Journal of Pharmacology and Experimental Therapeutics June 1, 2017, 361 (3) 408-416; DOI: https://doi.org/10.1124/jpet.116.238113
Research ArticleDrug Discovery and Translational Medicine
Inhibition of sEH Blocks Alveolar Bone Loss
Carlos Antonio Trindade-da-Silva, Ahmed Bettaieb, Marcelo Henrique Napimoga, Kin Sing Stephen Lee, Bora Inceoglu, Carlos Ueira-Vieira, Donald Bruun, Sumanta Kumar Goswami, Fawaz G. Haj and Bruce D. Hammock
Journal of Pharmacology and Experimental Therapeutics June 1, 2017, 361 (3) 408-416; DOI: https://doi.org/10.1124/jpet.116.238113
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