Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Disrupted Murine Gut–to–Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models
Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai and K. Sandy Pang
Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 174-191; DOI: https://doi.org/10.1124/jpet.116.236935
Edwin C. Y. Chow
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Holly P. Quach
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Yueping Zhang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Jason Z. Y. Wang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
David C. Evans
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Albert P. Li
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Jose Silva
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Rommel G. Tirona
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
Yurong Lai
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
K. Sandy Pang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Metabolism, Janssen Research and Development, LLC, Spring House, Pennsylvania (D.C.E., J.S.); In Vitro ADMET Laboratories, Columbia, Maryland (A.P.L.); Department of Physiology and Pharmacology and Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (R.G.T.)
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Instability of the Chimeric Humanized Liver Mouse Model
Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai and K. Sandy Pang
Journal of Pharmacology and Experimental Therapeutics January 1, 2017, 360 (1) 174-191; DOI: https://doi.org/10.1124/jpet.116.236935
Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Instability of the Chimeric Humanized Liver Mouse Model
Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai and K. Sandy Pang
Journal of Pharmacology and Experimental Therapeutics January 1, 2017, 360 (1) 174-191; DOI: https://doi.org/10.1124/jpet.116.236935
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