Abstract
Ammonium salts of organic acids have been given in large doses per os to dogs.
The CO2 combining power of plasma has been used to indicate the presence of any considerable amount of unoxidised acid.
It seems impossible to overstep the rate of oxidation of acetic, propionic and butyric acids (monocarboxylic acids).
Tricarboxylic acids (tricarballylic and citric) produce a consistent lowering of the CO2 combining power of plasma.
The dicarboxylic acids appear intermediate in effect.
Glutaric acid shows no nephropathic action in the dog when administered by mouth as ammonium salt.
Sodium tricarballylate acts as a renal irritant given intravenously or subcutaneously in the rabbit but not in the dog.
No alteration in blood chemistry was observed.
Doses of 40 grams a day of monoammonium citrate failed to produce any significant lowering of the CO2 combining power of plasma in a normal pregnant woman.
Footnotes
- Received March 25, 1929.
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