Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, Aik Jiang Lau, Laurie Alston, Thomas K. H. Chang, Sridhar Mani and Simon A. Hirota
Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 91-101; DOI: https://doi.org/10.1124/jpet.116.234096
Aditya Garg
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Angela Zhao
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Sarah L. Erickson
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Subhajit Mukherjee
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Aik Jiang Lau
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Laurie Alston
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Thomas K. H. Chang
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Sridhar Mani
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
Simon A. Hirota
Department of Physiology and Pharmacology (A.G., A.Z., S.L.E., L.A., S.A.H.), and Department of Microbiology, Immunology and Infectious Diseases (S.A.H.), University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Su.M., Sr.M.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.J.L., T.K.H.C.)
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In this issue
Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
PXR Regulates the Epithelial Barrier during Inflammation
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, Aik Jiang Lau, Laurie Alston, Thomas K. H. Chang, Sridhar Mani and Simon A. Hirota
Journal of Pharmacology and Experimental Therapeutics October 1, 2016, 359 (1) 91-101; DOI: https://doi.org/10.1124/jpet.116.234096
Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
PXR Regulates the Epithelial Barrier during Inflammation
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, Aik Jiang Lau, Laurie Alston, Thomas K. H. Chang, Sridhar Mani and Simon A. Hirota
Journal of Pharmacology and Experimental Therapeutics October 1, 2016, 359 (1) 91-101; DOI: https://doi.org/10.1124/jpet.116.234096
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