Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Shruthi Vaidhyanathan; Brynna Wilken-Resman; Daniel J. Ma; Karen E. Parrish; Rajendar K. Mittapalli; Brett L. Carlson; Jann N. Sarkaria; William F. Elmquist

doi:10.1124/jpet.115.229393

Research ArticleMetabolism, Transport, and Pharmacogenomics

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J. Ma, Karen E. Parrish, Rajendar K. Mittapalli, Brett L. Carlson, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 251-259; DOI: https://doi.org/10.1124/jpet.115.229393

Shruthi Vaidhyanathan

Department of Pharmaceutics, Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota (S.V., B.W.-R., K.E.P., R.K.M., W.F.E.); and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (D.J.M, B.L.C., J.N.S.)

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Brynna Wilken-Resman

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Daniel J. Ma

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Karen E. Parrish

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Rajendar K. Mittapalli

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Brett L. Carlson

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Jann N. Sarkaria

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William F. Elmquist

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Journal of Pharmacology and Experimental Therapeutics

Vol. 356, Issue 2

1 Feb 2016

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Research ArticleMetabolism, Transport, and Pharmacogenomics

GSK2126458 Distribution to the Brain

Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J. Ma, Karen E. Parrish, Rajendar K. Mittapalli, Brett L. Carlson, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics February 1, 2016, 356 (2) 251-259; DOI: https://doi.org/10.1124/jpet.115.229393

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Research ArticleMetabolism, Transport, and Pharmacogenomics

GSK2126458 Distribution to the Brain

Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J. Ma, Karen E. Parrish, Rajendar K. Mittapalli, Brett L. Carlson, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics February 1, 2016, 356 (2) 251-259; DOI: https://doi.org/10.1124/jpet.115.229393

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