Research ArticleInflammation, Immunopharmacology, and Asthma
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase
Thea K. Kleinschmidt, Martin Haraldsson, Devaraj Basavarajappa, Erik Lundeberg, Madhuranayaki Thulasingam, Maria Ekoff, Alexander Fauland, Christoph Lehmann, Astrid S. Kahnt, Lennart Lindbom and Jesper Z. Haeggström
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 108-116; DOI: https://doi.org/10.1124/jpet.115.227157
Thea K. Kleinschmidt
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Martin Haraldsson
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Devaraj Basavarajappa
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Erik Lundeberg
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Madhuranayaki Thulasingam
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Maria Ekoff
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Alexander Fauland
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Christoph Lehmann
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Astrid S. Kahnt
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Lennart Lindbom
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
Jesper Z. Haeggström
Department of Medical Biochemistry and Biophysics (T.K.K., D.B., M.T., A.F., J.Z.H.) and Chemical Biology Consortium Sweden, Science for Life Laboratory Stockholm, Department of Medical Biochemistry and Biophysics (M.H.), and Microvascular Physiology Research Group, Department of Physiology and Pharmacology (E.L., L.L.), Karolinska Institutet, Stockholm Sweden; Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden (M.E.); and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt/Main, Germany (C.L., A.S.K.)
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Research ArticleInflammation, Immunopharmacology, and Asthma
Potent and Selective Inhibitors of Human LTC4S
Thea K. Kleinschmidt, Martin Haraldsson, Devaraj Basavarajappa, Erik Lundeberg, Madhuranayaki Thulasingam, Maria Ekoff, Alexander Fauland, Christoph Lehmann, Astrid S. Kahnt, Lennart Lindbom and Jesper Z. Haeggström
Journal of Pharmacology and Experimental Therapeutics October 1, 2015, 355 (1) 108-116; DOI: https://doi.org/10.1124/jpet.115.227157
Research ArticleInflammation, Immunopharmacology, and Asthma
Potent and Selective Inhibitors of Human LTC4S
Thea K. Kleinschmidt, Martin Haraldsson, Devaraj Basavarajappa, Erik Lundeberg, Madhuranayaki Thulasingam, Maria Ekoff, Alexander Fauland, Christoph Lehmann, Astrid S. Kahnt, Lennart Lindbom and Jesper Z. Haeggström
Journal of Pharmacology and Experimental Therapeutics October 1, 2015, 355 (1) 108-116; DOI: https://doi.org/10.1124/jpet.115.227157
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement