Research ArticleDrug Discovery and Translational Medicine
PF-1355, a Mechanism-Based Myeloperoxidase Inhibitor, Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Glomerulonephritis
Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Athanasia Skoura, Jessica Ward, Kay Ahn, Amit Kalgutkar, Dexue Sun, Tristan S. Maurer, Paul D. Bonin, Carlin Okerberg, Walter Bobrowski, Thomas Kawabe, Yanwei Zhang, Timothy Coskran, Sammy Bell, Bhupesh Kapoor, Kent Johnson and Leonard Buckbinder
Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 288-298; DOI: https://doi.org/10.1124/jpet.114.221788
Wei Zheng
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Roscoe Warner
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Roger Ruggeri
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Chunyan Su
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Christian Cortes
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Athanasia Skoura
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Jessica Ward
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Kay Ahn
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Amit Kalgutkar
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Dexue Sun
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Tristan S. Maurer
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Paul D. Bonin
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Carlin Okerberg
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Walter Bobrowski
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Thomas Kawabe
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Yanwei Zhang
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Timothy Coskran
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Sammy Bell
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Bhupesh Kapoor
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Kent Johnson
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
Leonard Buckbinder
Pfizer World Wide Research and Development, Cambridge, Massachusetts (W.Z., R.R., C.S., C.C., A.S., J.W., K.A., A.K., D.S., T.S.M., Y.Z., B.K., L.B.); Department of Pathology, University of Michigan, Ann Arbor, Michigan (R.W., K.J.); and Pfizer World Wide Research and Development, Groton, Connecticut (P.D.B., C.O., W.B., T.K., T.C., S.B.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
MPO Inhibition Prevents Vasculitis and Anti-GBM Diseases
Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Athanasia Skoura, Jessica Ward, Kay Ahn, Amit Kalgutkar, Dexue Sun, Tristan S. Maurer, Paul D. Bonin, Carlin Okerberg, Walter Bobrowski, Thomas Kawabe, Yanwei Zhang, Timothy Coskran, Sammy Bell, Bhupesh Kapoor, Kent Johnson and Leonard Buckbinder
Journal of Pharmacology and Experimental Therapeutics May 1, 2015, 353 (2) 288-298; DOI: https://doi.org/10.1124/jpet.114.221788
Research ArticleDrug Discovery and Translational Medicine
MPO Inhibition Prevents Vasculitis and Anti-GBM Diseases
Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Athanasia Skoura, Jessica Ward, Kay Ahn, Amit Kalgutkar, Dexue Sun, Tristan S. Maurer, Paul D. Bonin, Carlin Okerberg, Walter Bobrowski, Thomas Kawabe, Yanwei Zhang, Timothy Coskran, Sammy Bell, Bhupesh Kapoor, Kent Johnson and Leonard Buckbinder
Journal of Pharmacology and Experimental Therapeutics May 1, 2015, 353 (2) 288-298; DOI: https://doi.org/10.1124/jpet.114.221788
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