Cough is a common reason that outpatients seek medical attention, yet therapeutic options for cough lack efficacy and are limited by safety and abuse liabilities. Memantine is an N-methyl-d-aspartate receptor channel blocker used in the treatment of Alzheimer’s disease. The goals of this study were to compare the antitussive effects of memantine, dextromethorphan, and codeine in guinea pigs, and to evaluate the effect of memantine in humans. In guinea pigs, memantine and codeine were both superior to dextromethorphan in the citric acid cough challenge model. Subsequently, healthy volunteers as well as adults with acute viral upper respiratory tract infection (URI) underwent capsaicin cough challenges after ingestion of memantine and matched placebo. In healthy volunteers, memantine significantly inhibited cough reflex sensitivity. In subjects with URI, responsiveness to capsaicin was markedly increased, and the inhibition of cough reflex sensitivity by memantine did not reach statistical significance (P = 0.088).
See article at J Pharmacol Exp Ther 2015, 352:448–454.
- Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics