Research ArticleToxicology
Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans
Lijiang Shen, Ashley Frazer-Abel, Paul R. Reynolds, Patricia C. Giclas, Alfred Chappell, Michael K. Pangburn, Husam Younis and Scott P. Henry
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 709-717; DOI: https://doi.org/10.1124/jpet.114.219378
Lijiang Shen
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Ashley Frazer-Abel
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Paul R. Reynolds
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Patricia C. Giclas
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Alfred Chappell
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Michael K. Pangburn
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Husam Younis
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
Scott P. Henry
Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.)
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Research ArticleToxicology
Mechanism and Sensitivity of Monkeys to AP Activation by ASO
Lijiang Shen, Ashley Frazer-Abel, Paul R. Reynolds, Patricia C. Giclas, Alfred Chappell, Michael K. Pangburn, Husam Younis and Scott P. Henry
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 709-717; DOI: https://doi.org/10.1124/jpet.114.219378
Research ArticleToxicology
Mechanism and Sensitivity of Monkeys to AP Activation by ASO
Lijiang Shen, Ashley Frazer-Abel, Paul R. Reynolds, Patricia C. Giclas, Alfred Chappell, Michael K. Pangburn, Husam Younis and Scott P. Henry
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 709-717; DOI: https://doi.org/10.1124/jpet.114.219378
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