Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Novel Orally Available Salvinorin A Analog PR-38 Inhibits Gastrointestinal Motility and Reduces Abdominal Pain in Mouse Models Mimicking Irritable Bowel Syndrome
M. Sałaga, P. R. Polepally, M. Sobczak, D. Grzywacz, W. Kamysz, A. Sibaev, M. Storr, J. C. Do Rego, J. K. Zjawiony and J. Fichna
Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 69-78; DOI: https://doi.org/10.1124/jpet.114.214239
M. Sałaga
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
P. R. Polepally
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
M. Sobczak
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
D. Grzywacz
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
W. Kamysz
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
A. Sibaev
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
M. Storr
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
J. C. Do Rego
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
J. K. Zjawiony
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
J. Fichna
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Novel Salvinorin A Analog PR-38 in IBS
M. Sałaga, P. R. Polepally, M. Sobczak, D. Grzywacz, W. Kamysz, A. Sibaev, M. Storr, J. C. Do Rego, J. K. Zjawiony and J. Fichna
Journal of Pharmacology and Experimental Therapeutics July 1, 2014, 350 (1) 69-78; DOI: https://doi.org/10.1124/jpet.114.214239
Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Novel Salvinorin A Analog PR-38 in IBS
M. Sałaga, P. R. Polepally, M. Sobczak, D. Grzywacz, W. Kamysz, A. Sibaev, M. Storr, J. C. Do Rego, J. K. Zjawiony and J. Fichna
Journal of Pharmacology and Experimental Therapeutics July 1, 2014, 350 (1) 69-78; DOI: https://doi.org/10.1124/jpet.114.214239
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