Research ArticleDrug Discovery and Translational Medicine
Pharmacological Evaluation of Selective α2c-Adrenergic Agonists in Experimental Animal Models of Nasal Congestion
Yanlin Jia, Garfield G. Mingo, John C. Hunter, Gissela B. Lieber, Jairam R. Palamanda, Hong Mei, Christopher W. Boyce, Michael C. Koss, Yongxin Yu, Milenko Cicmil, John A. Hey and Robbie L. McLeod
Journal of Pharmacology and Experimental Therapeutics April 2014, 349 (1) 75-84; DOI: https://doi.org/10.1124/jpet.113.210666
Yanlin Jia
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Garfield G. Mingo
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
John C. Hunter
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Gissela B. Lieber
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Jairam R. Palamanda
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Hong Mei
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Christopher W. Boyce
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Michael C. Koss
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Yongxin Yu
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Milenko Cicmil
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
John A. Hey
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
Robbie L. McLeod
Departments of In Vivo Pharmacology (G.G.M., J.C.H., G.B.L., M.C., J.A.H., R.L.M.) and Immunology (Y.J.), Merck Research Laboratories, Boston, Massachusetts; Departments of Pharmacokinetics (J.R.P., H.M.) and Chemistry (C.W.B.), Merck Research Laboratories, Rahway, New Jersey; and Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma (M.C.K., Y.Y.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Nasal Decongestive Effect of α2c-Adrenergic Agonists
Yanlin Jia, Garfield G. Mingo, John C. Hunter, Gissela B. Lieber, Jairam R. Palamanda, Hong Mei, Christopher W. Boyce, Michael C. Koss, Yongxin Yu, Milenko Cicmil, John A. Hey and Robbie L. McLeod
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 75-84; DOI: https://doi.org/10.1124/jpet.113.210666
Research ArticleDrug Discovery and Translational Medicine
Nasal Decongestive Effect of α2c-Adrenergic Agonists
Yanlin Jia, Garfield G. Mingo, John C. Hunter, Gissela B. Lieber, Jairam R. Palamanda, Hong Mei, Christopher W. Boyce, Michael C. Koss, Yongxin Yu, Milenko Cicmil, John A. Hey and Robbie L. McLeod
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 75-84; DOI: https://doi.org/10.1124/jpet.113.210666
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