Caveiolin-1 (Cav-1) is a plasmalemmal anchoring protein and modulator of vascular function and glucose homeostasis. Cav-1−/− mice show endothelial dysfunction, hyperglycemia, and increased blood pressure (BP). To test whether the pressor and vascular changes in cav-1 deficiency states are related to hyperglycemia and to assess the effect of metformin under these conditions, cav-1−/− mice were treated with placebo or metformin. BP and blood glucose were increased in cav-1−/−mice and did not change with metformin. In aortic rings, phenylephrine and KCl-induced contraction was less in cav-1−/−mice. Acetylcholine and nitroprusside-induced relaxation was greater in cav-1−/−mice. Metformin inhibited both vascular contraction and NO-cGMP-dependent relaxation. Because metformin had an impact on vasculature contraction in vitro but no effect on BP or blood glucose in vivo, there may be dissociation between hyperglycemia and altered vascular function in cav-1 deficiency states.
See article at J Pharmacol Exp Ther 2014 348:260–270.
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