Research ArticleDrug Discovery and Translational Medicine
Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo
Ronald Carnemolla, Colin F. Greineder, Ann-Marie Chacko, Kruti Rajan Patel, Bi-Sen Ding, Sergei Zaitsev, Charles T. Esmon and Vladimir R. Muzykantov
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 339-345; DOI: https://doi.org/10.1124/jpet.113.205104
Ronald Carnemolla
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Colin F. Greineder
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Ann-Marie Chacko
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Kruti Rajan Patel
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Bi-Sen Ding
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Sergei Zaitsev
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Charles T. Esmon
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
Vladimir R. Muzykantov
Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics (R.C., C.F.G., A.M.C., S.Z., and V.R.M.) and Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.M.C.); Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts (K.R.P.); Department of Genetic Medicine, Weill Cornell Medical College, New York, New York (B.S.D.); Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (C.T.E.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Targeted TM Generates APC under Oxidative Conditions
Ronald Carnemolla, Colin F. Greineder, Ann-Marie Chacko, Kruti Rajan Patel, Bi-Sen Ding, Sergei Zaitsev, Charles T. Esmon and Vladimir R. Muzykantov
Journal of Pharmacology and Experimental Therapeutics November 1, 2013, 347 (2) 339-345; DOI: https://doi.org/10.1124/jpet.113.205104
Research ArticleDrug Discovery and Translational Medicine
Targeted TM Generates APC under Oxidative Conditions
Ronald Carnemolla, Colin F. Greineder, Ann-Marie Chacko, Kruti Rajan Patel, Bi-Sen Ding, Sergei Zaitsev, Charles T. Esmon and Vladimir R. Muzykantov
Journal of Pharmacology and Experimental Therapeutics November 1, 2013, 347 (2) 339-345; DOI: https://doi.org/10.1124/jpet.113.205104
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