Research ArticleMetabolism, Transport, and Pharmacogenomics
Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [11C]Dehydropravastatin in Rats
Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yilong Cui, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 193-202; DOI: https://doi.org/10.1124/jpet.113.206425
Tomotaka Shingaki
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Tadayuki Takashima
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Ryosuke Ijuin
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Xuan Zhang
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Tomohiro Onoue
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Yumiko Katayama
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Takashi Okauchi
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Emi Hayashinaka
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Yilong Cui
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Yasuhiro Wada
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Masaaki Suzuki
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Kazuya Maeda
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Hiroyuki Kusuhara
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Yuichi Sugiyama
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
Yasuyoshi Watanabe
RIKEN Center for Life Science Technologies (T.S., Y.K., T.Ok., E.H., Y.C., Y.Wad., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences, Kobe, Hyogo, Japan (T.S., T.T., R.I., T.Ok., Y.K., E.H., Y.C., Y.Wad., M.S., Y.Wat.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (X.Z., T.On., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, Yokohama Bio Industry Center, Yokohama, Kanagawa, Japan (Y.S.)
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In this issue
Research ArticleMetabolism, Transport, and Pharmacogenomics
PET for Functional Analysis of Oatp and Mrp2
Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yilong Cui, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 193-202; DOI: https://doi.org/10.1124/jpet.113.206425
Research ArticleMetabolism, Transport, and Pharmacogenomics
PET for Functional Analysis of Oatp and Mrp2
Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yilong Cui, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 193-202; DOI: https://doi.org/10.1124/jpet.113.206425
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