The interaction of glucocorticoid-induced tumor necrosis factor receptor family-related (GITR) protein with its ligand (GITRL) modulates different functions, including immune/inflammatory response. Results from the present study indicate that adhesion of GITR−/− splenocytes to endothelial cells (EC) was reduced compared with wild-type cells, suggesting that the GITR-GITR interaction plays a role in adhesion. In a human in vitro model, the adhesion to human EC of HL-60 cells, differentiated toward the monocytic lineage, was increased by EC pretreatment with agonist GITR-Fc. Conversely, antagonistic anti-GITR and anti-GITRL Ab decreased adhesion. It is noteworthy that GITRL triggering increases ICAM-1 and VCAM-1 expression, and anti-ICAM-1 and anti-VCAM-1 Abs reverse GITR-Fc effects.
See article at J Pharmacol Exp Ther 2013, 347:164–172.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics