Multiple psychoactive synthetic cannabinoids (SCBs) are frequently used in combinations. This study investigated drug-drug interactions in vivo for Δ9-tetrahydrocannabinol (Δ9-THC)–like discriminative stimulus effects, analgesia, task disruption, and hypothermia by administering combinations of the prevalent SCBs (JWH-018 [(1-pentyl-1H-indole-3-yl)-1-naphthalenyl-methanone]/JWH-073 [(1-butyl-1H-indole-3-yl)-1-naphthalenylmethanone]) to mice. Synergism occurred in the Δ9-THC discrimination assay and in the tail-immersion assay, whereas an additive response for hypothermia and subadditive suppression of food-maintained responding was observed. Altogether, the results indicate that drug-drug interactions between JWH-018 and JWH-073 are effect- and ratio-dependent. Combinations may improve the therapeutic profile of cannabinoids, considering that analgesia, but not hypothermia or task disruption, was potentiated.
See article at J Pharmacol Exp Ther 2013, 346:350–361.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics