20-Hydroxyeicosatetraenoic acid (20-HETE) contributes to the migration and proliferation of vascular smooth muscle cells in vitro. The present study determined whether inhibition of 20-HETE production attenuates intimal hyperplasia and vascular remodeling in vivo. Rats underwent balloon injury of the common carotid artery and were treated with vehicle 1-aminobenzotriazole (ABT) or N-hydroxy-N′-(4-butyl-2-methylphenyl)-formamidine) (HET0016) for 14 days. There was a reduction of angiographic stenosis in the rats treated with 1-ABT and a reduction of the intima/media area ratios in the 1-ABT- and HET0016-treated rats. These results demonstrate that systemic administration of 1-ABT or HET0016 prevents the increase in 20-HETE levels and results in a reduction in intimal hyperplasia and vascular remodeling following endothelial injury.
See article at J Pharmacol Exp Ther 2013, 346:67–74.
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