Melatonin is considered to be a promising drug for treating glaucoma resulting from ocular hypertension. This study investigated the relationship between hypotension and interaction with adrenergic receptors. Melatonin caused β2-adrenergic receptor downregulation and α2A-adrenergic receptor upregulation in rabbit nonpigmented ciliary cells. Intraocular pressure experiments showed that the administration of a β-antagonist in rabbits pretreated with melatonin evoked greater hypotension in comparison with rabbits treated with a β-antagonist alone. Similar results were observed in animals treated with both melatonin and α2-adrenergic agonists, confirming the indirect action of melatonin on adrenergic receptors and the relationship of that action on ocular hypotension.
See article at J Pharmacol Exp Ther 2013, 346:138–145.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics