(±)-3,4-Methylenedioxymethamphetamine HCl (MDMA, Ecstasy) is a popular drug of abuse. This study characterized the behavioral effects of MDMA in a species closely related to humans. MDMA decreased food-maintained responding and increased bruxism. Drug blood level determination showed no MDMA after low doses and only modest levels following high doses. High metabolite levels were detected after all doses, suggesting extensive first-pass metabolism in the baboon. The present results demonstrate that MDMA produced behavioral effects in baboons that are similar to those reported in humans and that the blood levels of MDMA may not be predictive of the behavioral effects. Metabolites appear to play a role in the behavioral changes.
See article at J Pharmacol Exp Ther 2013, 345:342–353.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics