Scedosporium apiospermum is a fungus that can cause severe and often fatal cerebral infections. The aim of this study was to develop experimental models of disseminated scedosporiosis with cerebral involvement in immunocompetent and immunosuppressed rats. Cerebral involvement was confirmed by magnetic resonance imaging and histologic examination of the brain. Voriconazole or posaconazole was given to the rats, and effective doses were defined by a doubling of the survival time and the absence of neurologic sequelae. The results demonstrate that these models may constitute valuable tools for the performance of pharmacokinetic (PK) and pharmacodynamic (PD) studies for PK-PD modeling.
See article at J Pharmacol Exp Ther 2013, 345:198–205.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics