The purpose of this study was to examine whether puerarin reduced alcoholic liver injury. In rats, long-term alcohol intake caused pathological changes in the liver, increased endotoxin level in portal vein, and up-regulated protein expression of hepatic CD68 and lipopolysaccharide (LPS) receptors. The intestinal microvilli were observed to be sparse in conjunction with down-regulated intestinal zonula occludens-1 (ZO-1) protein. The hepatic pathological changes were inhibited in puerarin-treated animals, as well as the endotoxin level hepatic CD68 and LPS receptors. Pathological changes in intestinal microvillus and decreased intestinal ZO-1 were also ameliorated. These results suggest that puerarin affected alcohol-induced liver injury through inhibition on endotoxin gut-leakage, Kupffer cell activation, and LPS receptors.
See article at J Pharmacol Exp Ther 2013, 344:646–654.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics