Research ArticleCardiovascular
Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects
Sonia Donzelli, Gerry Fischer, Bruce S. King, Christin Niemann, Jenna F. DuMond, Jörg Heeren, Hartwig Wieboldt, Stephan Baldus, Christian Gerloff, Thomas Eschenhagen, Lucie Carrier, Rainer H. Böger and Michael Graham Espey
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 339-347; DOI: https://doi.org/10.1124/jpet.112.199836
Sonia Donzelli
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Gerry Fischer
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Bruce S. King
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Christin Niemann
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Jenna F. DuMond
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Jörg Heeren
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Hartwig Wieboldt
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Stephan Baldus
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Christian Gerloff
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Thomas Eschenhagen
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Lucie Carrier
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Rainer H. Böger
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
Michael Graham Espey
Department of Experimental Pharmacology and Toxicology (S.D., T.E., L.C.), Department of Neurology (S.D., C.G.), Department of Clinical Pharmacology and Toxicology (G.F., C.N., R.H.B.), Department of Molecular Cell Biology (J.H.), and Cardiovascular Research Center (S.D., S.B., T.E., L.C., R.H.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (G.F.); Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina (B.S.K., J.F.D.); Department of Cardiology, University Heart Center, Hamburg, Germany (H.W., S.B.); INSERM, Institut de Myologie, University Pierre et Marie Curie-Paris, Paris, France (L.C.); and Office of the Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.)
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In this issue
Research ArticleCardiovascular
HNO Donor in Cardiovascular Disease
Sonia Donzelli, Gerry Fischer, Bruce S. King, Christin Niemann, Jenna F. DuMond, Jörg Heeren, Hartwig Wieboldt, Stephan Baldus, Christian Gerloff, Thomas Eschenhagen, Lucie Carrier, Rainer H. Böger and Michael Graham Espey
Journal of Pharmacology and Experimental Therapeutics February 1, 2013, 344 (2) 339-347; DOI: https://doi.org/10.1124/jpet.112.199836
Research ArticleCardiovascular
HNO Donor in Cardiovascular Disease
Sonia Donzelli, Gerry Fischer, Bruce S. King, Christin Niemann, Jenna F. DuMond, Jörg Heeren, Hartwig Wieboldt, Stephan Baldus, Christian Gerloff, Thomas Eschenhagen, Lucie Carrier, Rainer H. Böger and Michael Graham Espey
Journal of Pharmacology and Experimental Therapeutics February 1, 2013, 344 (2) 339-347; DOI: https://doi.org/10.1124/jpet.112.199836
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