Steatotic grafts are excluded for use in partial liver transplantation due to increased risk of primary nonfunction. This study investigated the effects of suramin on the outcome of partial liver transplants of steatotic livers taken from rats dosed acutely with ethanol. Serum alanine aminotransferase (ALT) and total bilirubin, and hepatic necrosis and apoptosis were significantly higher after transplantation of fatty partial grafts from alcohol-treated rats. Suramin decreased ALT by 60%, hyperbilirubinemia by 75%, necrosis by 83%, and apoptosis by 70% after transplantation. All fatty partial graft recipients died within 5 days without suramin treatment. In contrast, 62% of the rats receiving fatty partial grafts and suramin survived for 5 days because of inhibition of tumor necrosis factor-α and transforming growth factor-β formation.
See article at J Pharmacol Exp Ther 2013, 344:417–425.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics