Research ArticleCardiovascular
A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias
Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Ryoko Hirakawa, Serge Karpinski, Cindy Hong Li, Lufei Hu, Xiao-Jun Li, William Crumb, Lin Wu, Dmitry Koltun, Jeff Zablocki, Lina Yao, Arvinder K. Dhalla, Sridharan Rajamani and John C. Shryock
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.198887
Luiz Belardinelli
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Gongxin Liu
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Cathy Smith-Maxwell
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Wei-Qun Wang
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Nesrine El-Bizri
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Ryoko Hirakawa
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Serge Karpinski
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Cindy Hong Li
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Lufei Hu
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Xiao-Jun Li
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
William Crumb
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Lin Wu
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Dmitry Koltun
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Jeff Zablocki
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Lina Yao
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Arvinder K. Dhalla
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
Sridharan Rajamani
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
John C. Shryock
Departments of Biology, Cardiovascular Therapeutic Area (L.B., G.L., C.S.M., W.Q.W., N.E.B., R.H., S.K., C.H.L., L.H., X.J.L., L.Y., A.K.D., S.R., J.C.S.), and Chemistry (D.K., J.Z.), Gilead Sciences, Fremont and Foster City, California; Department of Cardiology, Peking University, Beijing, China (L.W.); and Zenas Technologies, Metairie, Louisiana (W.C.)
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In this issue
Research ArticleCardiovascular
Selective Inhibition of Late INa Is Antiarrhythmic
Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Ryoko Hirakawa, Serge Karpinski, Cindy Hong Li, Lufei Hu, Xiao-Jun Li, William Crumb, Lin Wu, Dmitry Koltun, Jeff Zablocki, Lina Yao, Arvinder K. Dhalla, Sridharan Rajamani and John C. Shryock
Journal of Pharmacology and Experimental Therapeutics January 1, 2013, 344 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.198887
Research ArticleCardiovascular
Selective Inhibition of Late INa Is Antiarrhythmic
Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Ryoko Hirakawa, Serge Karpinski, Cindy Hong Li, Lufei Hu, Xiao-Jun Li, William Crumb, Lin Wu, Dmitry Koltun, Jeff Zablocki, Lina Yao, Arvinder K. Dhalla, Sridharan Rajamani and John C. Shryock
Journal of Pharmacology and Experimental Therapeutics January 1, 2013, 344 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.198887
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