Research ArticleDrug Discovery and Translational Medicine
LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria
Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris and Xiang Liu
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 167-178; DOI: https://doi.org/10.1124/jpet.112.199216
Thomas H. Beckham
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Ping Lu
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Elizabeth E. Jones
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Tucker Marrison
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Clayton S. Lewis
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Joseph C. Cheng
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Venkat K. Ramshesh
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Gyda Beeson
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Craig C. Beeson
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Richard R. Drake
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Alicja Bielawska
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Jacek Bielawski
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Zdzislaw M. Szulc
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Besim Ogretmen
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
James S. Norris
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
Xiang Liu
Department of Microbiology and Immunology (T.H.B., P.L., T.M., J.C.C., J.S.N., X.L.), Department of Biochemistry and Molecular Biology (A.B., J.B., Z.M.S., B.O.), College of Pharmacy/Pharmaceutical & Biomedical Sciences (G.B., C.C.B.), College of Pharmacy (C.S.L., V.K.R.), and Department of Cell and Molecular Pharmacology (E.E.J., R.R.D.), Medical University of South Carolina, Charleston, South Carolina
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Mito-Targeted Ceramide Kills Pancreatic Cancer
Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris and Xiang Liu
Journal of Pharmacology and Experimental Therapeutics January 1, 2013, 344 (1) 167-178; DOI: https://doi.org/10.1124/jpet.112.199216
Research ArticleDrug Discovery and Translational Medicine
Mito-Targeted Ceramide Kills Pancreatic Cancer
Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris and Xiang Liu
Journal of Pharmacology and Experimental Therapeutics January 1, 2013, 344 (1) 167-178; DOI: https://doi.org/10.1124/jpet.112.199216
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