Antisecretory drugs are commonly used for the treatment of gastric and duodenal ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The effects of H2-receptor antagonists (H2-RAs) and proton-pump inhibitors on NSAID-induced gastrointestinal lesions and small intestinal motility were examined in rats. Indomethacin produced lesions in the gastric corpus in fasted rats and in the small intestine in fed rats. H2-RAs and proton-pump inhibitors inhibited the formation of gastric lesions. The same drugs, except for lansoprazole, increased small intestinal lesions. The exacerbation of small intestinal lesions seemed to be related to activation of the cholinergic pathway and increased intestinal motility. The protection provided by lansoprazole was inhibited by ablation of the capsaicin-sensitive sensory neurons and inhibition of nitric oxide synthesis. The authors concluded that antisecretory drugs, with the exception of lansoprazole, may be inappropriate for the treatment of intestinal damage caused by NSAIDS.
See article at J Pharmacol Exp Ther 2012, 343:270–277.
- Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics