Mesenchymal stem cells (MSCs), because of their inherent multipotent nature and their ability to secrete a multitude of growth factors and cytokines, have been investigated for cardiac repair with encouraging results. Although stem cell transplantation is a promising therapeutic option to repair the infarcted heart, a number of challenges are involved. One of the challenges is survival of the transplanted cells in the ischemic region because of excessive stress. This study investigated the effects of carvedilol, a nonselective β-adrenergic receptor blocker with antioxidant properties on the survival and engraftment of MSCs in the infracted heart. MSCs were subjected to a simulated host tissue environment, similar to the one present in the infracted myocardium, by culturing them in the presence of hydrogen peroxide (H2O2) to induce oxidative stress. When treated with carvedilol, cells exhibited significant protection against H2O2-induced cell death. Similarly, transplantation of MSCs and treatment of animals with carvedilol led to significant improvement in cardiac function compared with treatment by MSCs alone.
See article at J Pharmacol Exp Ther 2012, 343:62–71.
- Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics