Research ArticleMetabolism, Transport, and Pharmacogenomics
Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter
Alan Menter, Breck Thrash, Christina Cherian, Larry H. Matherly, Lei Wang, Aleem Gangjee, Joel R. Morgan, Dean Y. Maeda, Aaron D. Schuler, Stuart J. Kahn and John A. Zebala
Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 696-708; DOI: https://doi.org/10.1124/jpet.112.195479
Alan Menter
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Breck Thrash
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Christina Cherian
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Larry H. Matherly
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Lei Wang
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Aleem Gangjee
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Joel R. Morgan
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Dean Y. Maeda
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Aaron D. Schuler
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
Stuart J. Kahn
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
John A. Zebala
Baylor Research Institute, Dallas, Texas (A.M., B.T.); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (C.C., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.); and Syntrix Biosystems Inc., Auburn, Washington (J.R.M., D.Y.M., A.D.S., S.J.K., J.A.Z.)
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In this issue
Research ArticleMetabolism, Transport, and Pharmacogenomics
Stereoselective Transport of Aminopterin Enantiomers
Alan Menter, Breck Thrash, Christina Cherian, Larry H. Matherly, Lei Wang, Aleem Gangjee, Joel R. Morgan, Dean Y. Maeda, Aaron D. Schuler, Stuart J. Kahn and John A. Zebala
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 696-708; DOI: https://doi.org/10.1124/jpet.112.195479
Research ArticleMetabolism, Transport, and Pharmacogenomics
Stereoselective Transport of Aminopterin Enantiomers
Alan Menter, Breck Thrash, Christina Cherian, Larry H. Matherly, Lei Wang, Aleem Gangjee, Joel R. Morgan, Dean Y. Maeda, Aaron D. Schuler, Stuart J. Kahn and John A. Zebala
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 696-708; DOI: https://doi.org/10.1124/jpet.112.195479
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