Abstract
With the incidence of respiratory diseases increasing throughout the world, new therapies are needed. This review provides a short overview of different imaging techniques of interest for drug discovery and development within the pulmonary disease area. The focus is on studies performed in both animals and humans, which are of importance for understanding pathophysiological aspects and evaluating new drugs. Rather than emphasizing particular lung diseases, the noninvasive diagnosis and quantification of a number of characteristics related to several pathological conditions of the lung are addressed: inflammation, mucus secretion and clearance, emphysema, ventilation, perfusion, fibrosis, airway remodeling, and pulmonary arterial hypertension. Techniques are discussed based on their present use or potential future utilization in the context of drug studies.
Footnotes
N.B. has been supported by an award from the 3R Research Foundation, Muensingen, Switzerland [Project 82/02].
Article, publication date, and citation information can be found at http://jpet.aspetjournals.org.
doi:10.1124/jpet.110.172635.
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ABBREVIATIONS:
- COPD
- chronic obstructive pulmonary disease
- 3D
- three-dimensional
- ADC
- apparent diffusion coefficient
- BAL
- bronchoalveolar lavage
- CF
- cystic fibrosis
- CT
- computerized tomography
- HRCT
- high-resolution CT
- SPECT
- single-photon emission CT
- FDG
- fluorodeoxyglucose
- HP
- hyperpolarized
- LPS
- lipopolysaccharide
- MR
- magnetic resonance
- MRI
- MR imaging
- NIRF
- near-IR fluorescence
- OVA
- ovalbumin
- PAP
- pulmonary arterial pressure
- PET
- positron emission tomography
- RBC
- red blood cell
- RHC
- right heart catheterization
- V/Q
- ventilation to perfusion
- DNK333
- N-((R,R)-(E)-1-(3,4-dichlorobenzyl)-3-(2-oxoazepan-3-yl)carbamoyl)allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide.
- Received July 9, 2010.
- Accepted January 3, 2011.
- Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics
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