Nicotinic mechanisms may substantially contribute to monoaminergic psychomotor stimulant drug abuse-related behavioral effects, possibly through modulation of dopaminergic neurotransmission. The study by Desai and Bergman continued to investigate the contribution of the acetylcholine nicotinic system in the abuse-related effects of d-methamphetamine (d-MA). All indirect dopamine agonists fully substituted for d-MA; however, only (−)-nicotine fully substituted for d-MA, whereas other nicotinic agonists and muscarinic antagonists produced only partial d-MA like response. These results suggest that the effects of (−)-nicotine and monoaminergic stimulants involve common dopamine receptor-mediated effects. The different effects observed with various nicotinic agonists suggest that the d-MA-like effects of these nicotinic agonists may be attributed to their ability to stimulate dopamine release. These results also raise the possibility that the d-MA-like effects of nicotinic agonists are not invariantly linked to dopamine release and that other neurochemical mechanisms also play a prominent role in the overlapping behavioral effects of nicotinic and monoaminergic stimulants.
See article at J Pharmacol Exp Ther 2010, 335:807–816.
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