Research ArticleNEUROPHARMACOLOGY
Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist
Christopher A. Salvatore, Eric L. Moore, Amy Calamari, Jacquelynn J. Cook, Maria S. Michener, Stacey O'Malley, Patricia J. Miller, Cyrille Sur, David L. Williams Jr., Zhizhen Zeng, Andrew Danziger, Joseph J. Lynch, Christopher P. Regan, John F. Fay, Yui S. Tang, Chi-Chung Li, Nicole T. Pudvah, Rebecca B. White, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Harold G. Selnick, Joseph P. Vacca and Stefanie A. Kane
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 152-160; DOI: https://doi.org/10.1124/jpet.109.163816
Christopher A. Salvatore
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Eric L. Moore
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Amy Calamari
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Jacquelynn J. Cook
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Maria S. Michener
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Stacey O'Malley
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Patricia J. Miller
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Cyrille Sur
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
David L. Williams Jr.
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Zhizhen Zeng
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Andrew Danziger
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Joseph J. Lynch
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Christopher P. Regan
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
John F. Fay
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Yui S. Tang
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Chi-Chung Li
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Nicole T. Pudvah
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Rebecca B. White
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Ian M. Bell
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Steven N. Gallicchio
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Samuel L. Graham
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Harold G. Selnick
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Joseph P. Vacca
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
Stefanie A. Kane
Departments of Pain/Migraine (C.A.S., E.L.M., A.C., S.A.K.), Imaging (J.J.C., M.S.M., S.O., P.J.M., C.S., D.L.W., Z.Z.), Central Pharmacology (A.D., J.J.L., C.P.R.), In Vitro Sciences (J.F.F.), Clinical PK/PD (C.-C.L.), Preclinical DMPK (N.T.P., R.B.W.), and Medicinal Chemistry (I.M.B., S.N.G., S.L.G., H.G.S., J.P.V.), Merck Research Laboratories, West Point, Pennsylvania; and Department of Labeled Compound Synthesis, Merck Research Laboratories, Rahway, New Jersey (Y.S.T.)
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Research ArticleNEUROPHARMACOLOGY
Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist
Christopher A. Salvatore, Eric L. Moore, Amy Calamari, Jacquelynn J. Cook, Maria S. Michener, Stacey O'Malley, Patricia J. Miller, Cyrille Sur, David L. Williams, Zhizhen Zeng, Andrew Danziger, Joseph J. Lynch, Christopher P. Regan, John F. Fay, Yui S. Tang, Chi-Chung Li, Nicole T. Pudvah, Rebecca B. White, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Harold G. Selnick, Joseph P. Vacca and Stefanie A. Kane
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 152-160; DOI: https://doi.org/10.1124/jpet.109.163816
Research ArticleNEUROPHARMACOLOGY
Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist
Christopher A. Salvatore, Eric L. Moore, Amy Calamari, Jacquelynn J. Cook, Maria S. Michener, Stacey O'Malley, Patricia J. Miller, Cyrille Sur, David L. Williams, Zhizhen Zeng, Andrew Danziger, Joseph J. Lynch, Christopher P. Regan, John F. Fay, Yui S. Tang, Chi-Chung Li, Nicole T. Pudvah, Rebecca B. White, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Harold G. Selnick, Joseph P. Vacca and Stefanie A. Kane
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 152-160; DOI: https://doi.org/10.1124/jpet.109.163816
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