Table of Contents

May 2007; 321 (2)

PERSPECTIVES IN PHARMACOLOGY

    • Donald E. Mager and
    • Darrell R. Abernethy

    Use of Wavelet and Fast Fourier Transforms in Pharmacodynamics

    J Pharmacol Exp Ther May 2007 321:423-430; published ahead of print December 1, 2006, doi:10.1124/jpet.106.113183

ENDOCRINE AND DIABETES

    • Emilio Ruiz,
    • Santiago Redondo,
    • Antonio Gordillo-Moscoso,
    • and Teresa Tejerina

    Pioglitazone Induces Apoptosis in Human Vascular Smooth Muscle Cells from Diabetic Patients Involving the Transforming Growth Factor-β/Activin Receptor-Like Kinase-4/5/7/Smad2 Signaling Pathway

    J Pharmacol Exp Ther May 2007 321:431-438; published ahead of print January 31, 2007, doi:10.1124/jpet.106.114934
    • Noelia Rivera,
    • Carrie A. Everett-Grueter,
    • Dale S. Edgerton,
    • Tiffany Rodewald,
    • Doss W. Neal,
    • Erica Nishimura,
    • Marianne O. Larsen,
    • Lene O. Jacobsen,
    • Kim Kristensen,
    • Christian L. Brand,
    • and Alan D. Cherrington

    A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog

    J Pharmacol Exp Ther May 2007 321:743-752; published ahead of print February 16, 2007, doi:10.1124/jpet.106.115717

NEUROPHARMACOLOGY

    • Enrique Sánchez-Pastor,
    • Xóchitl Trujillo,
    • Miguel Huerta,
    • and Felipa Andrade

    Effects of Cannabinoids on Synaptic Transmission in the Frog Neuromuscular Junction

    J Pharmacol Exp Ther May 2007 321:439-445; published ahead of print January 31, 2007, doi:10.1124/jpet.106.116319
    • Magali Peeters,
    • Martin J. Gunthorpe,
    • Paul J. L. M. Strijbos,
    • Paul Goldsmith,
    • Neil Upton,
    • and Michael F. James

    Effects of Pan- and Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists on Cortical Spreading Depression in the Rat: Therapeutic Potential for Migraine

    J Pharmacol Exp Ther May 2007 321:564-572; published ahead of print January 31, 2007, doi:10.1124/jpet.106.117101
    • Ashraf Yassen,
    • Jingmin Kan,
    • Erik Olofsen,
    • Ernst Suidgeest,
    • Albert Dahan,
    • and Meindert Danhof

    Pharmacokinetic-Pharmacodynamic Modeling of the Respiratory Depressant Effect of Norbuprenorphine in Rats

    J Pharmacol Exp Ther May 2007 321:598-607; published ahead of print February 5, 2007, doi:10.1124/jpet.106.115972
    • Daya S. Gupta,
    • Hans von Gizycki,
    • and Alan R. Gintzler

    Sex-/Ovarian Steroid-Dependent Release of Endomorphin 2 from Spinal Cord

    J Pharmacol Exp Ther May 2007 321:635-641; published ahead of print February 16, 2007, doi:10.1124/jpet.106.118505
    • Pascal Bonaventure,
    • Lisa Kelly,
    • Leah Aluisio,
    • Jonathan Shelton,
    • Brian Lord,
    • Ruggero Galici,
    • Kirsten Miller,
    • John Atack,
    • Timothy W. Lovenberg,
    • and Christine Dugovic

    Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

    J Pharmacol Exp Ther May 2007 321:690-698; published ahead of print February 21, 2007, doi:10.1124/jpet.107.119404
    • Jean D. Deupree,
    • Abbey L. Reed,
    • and David B. Bylund

    Differential Effects of the Tricyclic Antidepressant Desipramine on the Density of Adrenergic Receptors in Juvenile and Adult Rats

    J Pharmacol Exp Ther May 2007 321:770-776; published ahead of print February 9, 2007, doi:10.1124/jpet.106.118935
    • Akira Nakajima,
    • Tohru Yamakuni,
    • Kentaro Matsuzaki,
    • Norihito Nakata,
    • Hiroshi Onozuka,
    • Akihito Yokosuka,
    • Yutaka Sashida,
    • Yoshihiro Mimaki,
    • and Yasushi Ohizumi

    Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment Associated with N-Methyl-D-aspartate Receptor Antagonism by Activation of Extracellular Signal-Regulated Kinase Signaling

    J Pharmacol Exp Ther May 2007 321:784-790; published ahead of print February 8, 2007, doi:10.1124/jpet.106.117010
    • Lei Tang,
    • Yan Chen,
    • Zili Chen,
    • Peter M. Blumberg,
    • Alan P. Kozikowski,
    • and Zaijie Jim Wang

    Antinociceptive Pharmacology of N-(4-Chlorobenzyl)-N′-(4-hydroxy-3-iodo-5-methoxybenzyl) Thiourea, a High-Affinity Competitive Antagonist of the Transient Receptor Potential Vanilloid 1 Receptor

    J Pharmacol Exp Ther May 2007 321:791-798; published ahead of print February 20, 2007, doi:10.1124/jpet.106.117572
    • Soo Bin Yim,
    • Sang Eun Park,
    • and Chung Soo Lee

    Protective Effect of Glycyrrhizin on 1-Methyl-4-phenylpyridinium-Induced Mitochondrial Damage and Cell Death in Differentiated PC12 Cells

    J Pharmacol Exp Ther May 2007 321:816-822; published ahead of print February 21, 2007, doi:10.1124/jpet.107.119602

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • K. Trent Moreland,
    • Jesse D. Procknow,
    • Randy S. Sprague,
    • Jennifer L. Iverson,
    • Andrew J. Lonigro,
    • and Alan H. Stephenson

    Cyclooxygenase (COX)-1 and COX-2 Participate in 5,6-Epoxyeicosatrienoic Acid-Induced Contraction of Rabbit Intralobar Pulmonary Arteries

    J Pharmacol Exp Ther May 2007 321:446-454; published ahead of print January 31, 2007, doi:10.1124/jpet.106.107904
    • Chirag A. Patel and
    • Satish Rattan

    RhoA Prenylation Inhibitor Produces Relaxation of Tonic Smooth Muscle of Internal Anal Sphincter

    J Pharmacol Exp Ther May 2007 321:501-508; published ahead of print February 22, 2007, doi:10.1124/jpet.107.119339
    • Joanna E. Adrian,
    • Klaas Poelstra,
    • Gerrit L. Scherphof,
    • Dirk K. F. Meijer,
    • Anne-miek van Loenen-Weemaes,
    • Catharina Reker-Smit,
    • Henriëtte W. M. Morselt,
    • Peter Zwiers,
    • and Jan A. A. M. Kamps

    Effects of a New Bioactive Lipid-Based Drug Carrier on Cultured Hepatic Stellate Cells and Liver Fibrosis in Bile Duct-Ligated Rats

    J Pharmacol Exp Ther May 2007 321:536-543; published ahead of print February 21, 2007, doi:10.1124/jpet.106.117945
    • Toshiyuki Takasu,
    • Masashi Ukai,
    • Shuichi Sato,
    • Tetsuo Matsui,
    • Itsuro Nagase,
    • Tatsuya Maruyama,
    • Masao Sasamata,
    • Keiji Miyata,
    • Hisashi Uchida,
    • and Osamu Yamaguchi

    Effect of (R)-2-(2-Aminothiazol-4-yl)-4′-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} Acetanilide (YM178), a Novel Selective β3-Adrenoceptor Agonist, on Bladder Function

    J Pharmacol Exp Ther May 2007 321:642-647; published ahead of print February 9, 2007, doi:10.1124/jpet.106.115840
    • Edwin K. Jackson,
    • Zaichuan Mi,
    • Lefteris C. Zacharia,
    • Stevan P. Tofovic,
    • and Raghvendra K. Dubey

    The Pancreatohepatorenal cAMP-Adenosine Mechanism

    J Pharmacol Exp Ther May 2007 321:799-809; published ahead of print February 21, 2007, doi:10.1124/jpet.106.119164
    • Edwin K. Jackson,
    • Jin Ren,
    • Lefteris C. Zacharia,
    • and Zaichuan Mi

    Characterization of Renal Ecto-Phosphodiesterase

    J Pharmacol Exp Ther May 2007 321:810-815; published ahead of print February 16, 2007, doi:10.1124/jpet.106.119057

CARDIOVASCULAR

    • Ming-Hong Tai,
    • Wen-Tsan Weng,
    • Wan-Chen Lo,
    • Julie Y. H. Chan,
    • Che-Jen Lin,
    • Hing-Chung Lam,
    • and Ching-Jiunn Tseng

    Role of Nitric Oxide in α-Melanocyte-Stimulating Hormone-Induced Hypotension in the Nucleus Tractus Solitarii of the Spontaneously Hypertensive Rats

    J Pharmacol Exp Ther May 2007 321:455-461; published ahead of print February 5, 2007, doi:10.1124/jpet.106.118299
    • Yanping Cheng,
    • Isaac George,
    • Geng-Hua Yi,
    • Steven Reiken,
    • Anguo Gu,
    • Yuankai Kenny Tao,
    • Jordan Muraskin,
    • Siyi Qin,
    • Kun-Lun He,
    • Ilan Hay,
    • Kenward Yu,
    • Mehmet C. Oz,
    • Daniel Burkhoff,
    • Jeffrey Holmes,
    • and Jie Wang

    Bradycardic Therapy Improves Left Ventricular Function and Remodeling in Dogs with Coronary Embolization-Induced Chronic Heart Failure

    J Pharmacol Exp Ther May 2007 321:469-476; published ahead of print February 2, 2007, doi:10.1124/jpet.106.118109
    • Ben J. Wu,
    • Nick Di Girolamo,
    • Konstanze Beck,
    • Colm G. Hanratty,
    • Katherine Choy,
    • Jing Y. Hou,
    • Michael R. Ward,
    • and Roland Stocker

    Probucol [4,4′-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] Inhibits Compensatory Remodeling and Promotes Lumen Loss Associated with Atherosclerosis in Apolipoprotein E-Deficient Mice

    J Pharmacol Exp Ther May 2007 321:477-484; published ahead of print February 9, 2007, doi:10.1124/jpet.106.118612
    • Wei Ni,
    • Gregory D. Fink,
    • and Stephanie W. Watts

    The 5-Hydroxytryptamine2A Receptor Is Involved in (+)-Norfenfluramine-Induced Arterial Contraction and Blood Pressure Increase in Deoxycorticosterone Acetate-Salt Hypertension

    J Pharmacol Exp Ther May 2007 321:485-491; published ahead of print February 8, 2007, doi:10.1124/jpet.106.114017
    • Gulnura Karagulova,
    • Yuankun Yue,
    • Abel Moreyra,
    • Mohamed Boutjdir,
    • and Irina Korichneva

    Protective Role of Intracellular Zinc in Myocardial Ischemia/Reperfusion Is Associated with Preservation of Protein Kinase C Isoforms

    J Pharmacol Exp Ther May 2007 321:517-525; published ahead of print February 22, 2007, doi:10.1124/jpet.107.119644
    • Dennis Rottlaender,
    • Jan Matthes,
    • Stephen F. Vatner,
    • Roland Seifert,
    • and Stefan Herzig

    Functional Adenylyl Cyclase Inhibition in Murine Cardiomyocytes by 2′(3′)-O-(N-Methylanthraniloyl)-Guanosine 5′-[γ-Thio]triphosphate

    J Pharmacol Exp Ther May 2007 321:608-615; published ahead of print February 6, 2007, doi:10.1124/jpet.106.118422
    • Yong Lim,
    • Tack-Joong Kim,
    • Yong-Ri Jin,
    • Dong-Woon Kim,
    • Jin-Sook Kwon,
    • Ju-Hee Son,
    • Jae-Chul Jung,
    • Mitchell A. Avery,
    • Dong Ju Son,
    • Jin Tae Hong,
    • and Yeo-Pyo Yun

    Epothilone B Inhibits Neointimal Formation after Rat Carotid Injury through the Regulation of Cell Cycle-Related Proteins

    J Pharmacol Exp Ther May 2007 321:648-655; published ahead of print February 8, 2007, doi:10.1124/jpet.106.117622
    • Saoirse E. O'Sullivan,
    • Michael D. Randall,
    • and Sheila M. Gardiner

    The in Vitro and in Vivo Cardiovascular Effects of Δ9-Tetrahydrocannabinol in Rats Made Hypertensive by Chronic Inhibition of Nitric-Oxide Synthase

    J Pharmacol Exp Ther May 2007 321:663-672; published ahead of print February 6, 2007, doi:10.1124/jpet.106.116566
    • Alkje Moritz,
    • Ronald Gust,
    • and Heinz H. Pertz

    Characterization of the Relaxant Response to N,N′-Dipropyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine in Porcine Coronary Arteries

    J Pharmacol Exp Ther May 2007 321:699-706; published ahead of print February 22, 2007, doi:10.1124/jpet.107.120337
    • Sung Eun Kim,
    • Hye Sook Ahn,
    • Bok Hee Choi,
    • Hyun-Jong Jang,
    • Myung-Jun Kim,
    • Duck-Joo Rhie,
    • Shin-Hee Yoon,
    • Yang-Hyeok Jo,
    • Myung-Suk Kim,
    • Ki-Wug Sung,
    • and Sang June Hahn

    Open Channel Block of A-Type, Kv4.3, and Delayed Rectifier K+ Channels, Kv1.3 and Kv3.1, by Sibutramine

    J Pharmacol Exp Ther May 2007 321:753-762; published ahead of print February 20, 2007, doi:10.1124/jpet.106.117747
    • Youping Wang,
    • Norbert E. Kaminski,
    • and Donna H. Wang

    Endocannabinoid Regulates Blood Pressure via Activation of the Transient Receptor Potential Vanilloid Type 1 in Wistar Rats Fed a High-Salt Diet

    J Pharmacol Exp Ther May 2007 321:763-769; published ahead of print February 16, 2007, doi:10.1124/jpet.106.112904

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

    • Jun Yang,
    • Hongtao Chen,
    • Iontcho R. Vlahov,
    • Ji-Xin Cheng,
    • and Philip S. Low

    Characterization of the pH of Folate Receptor-Containing Endosomes and the Rate of Hydrolysis of Internalized Acid-Labile Folate-Drug Conjugates

    J Pharmacol Exp Ther May 2007 321:462-468; published ahead of print February 8, 2007, doi:10.1124/jpet.106.117648
    • Jennifer B. Dennison,
    • David R. Jones,
    • Jamie L. Renbarger,
    • and Stephen D. Hall

    Effect of CYP3A5 Expression on Vincristine Metabolism with Human Liver Microsomes

    J Pharmacol Exp Ther May 2007 321:553-563; published ahead of print February 1, 2007, doi:10.1124/jpet.106.118471
    • Natasha T. Snider,
    • Andrei M. Kornilov,
    • Ute M. Kent,
    • and Paul F. Hollenberg

    Anandamide Metabolism by Human Liver and Kidney Microsomal Cytochrome P450 Enzymes to Form Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acid Ethanolamides

    J Pharmacol Exp Ther May 2007 321:590-597; published ahead of print February 1, 2007, doi:10.1124/jpet.107.119321
    • Xiao-Yan Chu,
    • Kelly Bleasby,
    • Jocelyn Yabut,
    • Xiaoxin Cai,
    • Grace Hoyee Chan,
    • Michael J. Hafey,
    • Shiyao Xu,
    • Arthur J. Bergman,
    • Matthew P. Braun,
    • Dennis C. Dean,
    • and Raymond Evers

    Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein

    J Pharmacol Exp Ther May 2007 321:673-683; published ahead of print February 21, 2007, doi:10.1124/jpet.106.116517
    • Jun-ichi Asaka,
    • Tomohiro Terada,
    • Ken Ogasawara,
    • Toshiya Katsura,
    • and Ken-ichi Inui

    Characterization of the Basal Promoter Element of Human Organic Cation Transporter 2 Gene

    J Pharmacol Exp Ther May 2007 321:684-689; published ahead of print February 21, 2007, doi:10.1124/jpet.106.118695
    • Feng Liu,
    • Christine C. Conwell,
    • Xing Yuan,
    • Lisa M. Shollenberger,
    • and Leaf Huang

    Novel Nonviral Vectors Target Cellular Signaling Pathways: Regulated Gene Expression and Reduced Toxicity

    J Pharmacol Exp Ther May 2007 321:777-783; published ahead of print February 21, 2007, doi:10.1124/jpet.106.118117

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

    • Isabella Dell'Aica,
    • Raffaele Niero,
    • Francesco Piazza,
    • Anna Cabrelle,
    • Luigi Sartor,
    • Cristiano Colalto,
    • Enrico Brunetta,
    • Girieca Lorusso,
    • Roberto Benelli,
    • Adriana Albini,
    • Fiorella Calabrese,
    • Carlo Agostini,
    • and Spiridione Garbisa

    Hyperforin Blocks Neutrophil Activation of Matrix Metalloproteinase-9, Motility and Recruitment, and Restrains Inflammation-Triggered Angiogenesis and Lung Fibrosis

    J Pharmacol Exp Ther May 2007 321:492-500; published ahead of print February 8, 2007, doi:10.1124/jpet.106.116459
    • Woods Wannamaker,
    • Robert Davies,
    • Mark Namchuk,
    • John Pollard,
    • Pamella Ford,
    • George Ku,
    • Caroline Decker,
    • Paul Charifson,
    • Peter Weber,
    • Ursula A. Germann,
    • Keisuke Kuida,
    • and John C. R. Randle

    (S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

    J Pharmacol Exp Ther May 2007 321:509-516; published ahead of print February 8, 2007, doi:10.1124/jpet.106.111344
    • Paula Urquhart,
    • Guglielmo Rosignoli,
    • Dianne Cooper,
    • Roberto Motterlini,
    • and Mauro Perretti

    Carbon Monoxide-Releasing Molecules Modulate Leukocyte-Endothelial Interactions under Flow

    J Pharmacol Exp Ther May 2007 321:656-662; published ahead of print February 8, 2007, doi:10.1124/jpet.106.117218
    • Yann Pellequer,
    • Yvette Meissner,
    • Nathalie Ubrich,
    • and Alf Lamprecht

    Epithelial Heparin Delivery via Microspheres Mitigates Experimental Colitis in Mice

    J Pharmacol Exp Ther May 2007 321:726-733; published ahead of print February 22, 2007, doi:10.1124/jpet.106.117226
    • Robert Newton,
    • Neil S. Holden,
    • Matthew C. Catley,
    • Wale Oyelusi,
    • Richard Leigh,
    • David Proud,
    • and Peter J. Barnes

    Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule IκB Kinase Inhibitors

    J Pharmacol Exp Ther May 2007 321:734-742; published ahead of print February 22, 2007, doi:10.1124/jpet.106.118125

TOXICOLOGY

    • Isabelle Larosche,
    • Philippe Lettéron,
    • Bernard Fromenty,
    • Nathalie Vadrot,
    • Adjé Abbey-Toby,
    • Gérard Feldmann,
    • Dominique Pessayre,
    • and Abdellah Mansouri

    Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver

    J Pharmacol Exp Ther May 2007 321:526-535; published ahead of print February 2, 2007, doi:10.1124/jpet.106.114546
    • Gilbert R. Kinsey,
    • Jane McHowat,
    • Kennerly S. Patrick,
    • and Rick G. Schnellmann

    Role of Ca2+-Independent Phospholipase A2γ in Ca2+-Induced Mitochondrial Permeability Transition

    J Pharmacol Exp Ther May 2007 321:707-715; published ahead of print February 20, 2007, doi:10.1124/jpet.107.119545

CELLULAR AND MOLECULAR

    • Danxin Wang,
    • Xiaochun Sun,
    • and Wolfgang Sadee

    Different Effects of Opioid Antagonists on μ-, δ-, and κ-Opioid Receptors with and without Agonist Pretreatment

    J Pharmacol Exp Ther May 2007 321:544-552; published ahead of print January 31, 2007, doi:10.1124/jpet.106.118810
    • Nina Roos,
    • Nicolas Poulalhon,
    • Dominique Farge,
    • Isabelle Madelaine,
    • Alain Mauviel,
    • and Franck Verrecchia

    In Vitro Evidence for a Direct Antifibrotic Role of the Immunosuppressive Drug Mycophenolate Mofetil

    J Pharmacol Exp Ther May 2007 321:583-589; published ahead of print February 1, 2007, doi:10.1124/jpet.106.117051
    • Dorrah Deeb,
    • Hao Jiang,
    • Xiaohua Gao,
    • Shaza Al-Holou,
    • Andrew L. Danyluk,
    • Scott A. Dulchavsky,
    • and Subhash C. Gautam

    Curcumin [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1–6-heptadine-3,5-dione; C21H20O6] Sensitizes Human Prostate Cancer Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand/Apo2L-Induced Apoptosis by Suppressing Nuclear Factor-κB via Inhibition of the Prosurvival Akt Signaling Pathway

    J Pharmacol Exp Ther May 2007 321:616-625; published ahead of print February 8, 2007, doi:10.1124/jpet.106.117721
    • Antonella Liantonio,
    • Viviana Giannuzzi,
    • Valentina Cippone,
    • Giulia Maria Camerino,
    • Sabata Pierno,
    • and Diana Conte Camerino

    Fluvastatin and Atorvastatin Affect Calcium Homeostasis of Rat Skeletal Muscle Fibers in Vivo and in Vitro by Impairing the Sarcoplasmic Reticulum/Mitochondria Ca2+-Release System

    J Pharmacol Exp Ther May 2007 321:626-634; published ahead of print February 9, 2007, doi:10.1124/jpet.106.118331

BEHAVIORAL PHARMACOLOGY

    • Jennifer L. Martelle,
    • Renee Claytor,
    • Jason T. Ross,
    • Beth A. Reboussin,
    • Amy Hauck Newman,
    • and Michael A. Nader

    Effects of Two Novel D3-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys

    J Pharmacol Exp Ther May 2007 321:573-582; published ahead of print February 1, 2007, doi:10.1124/jpet.106.113571
    • Frank G. Boess,
    • Jean De Vry,
    • Christina Erb,
    • Timo Flessner,
    • Martin Hendrix,
    • Joachim Luithle,
    • Christoph Methfessel,
    • Bernd Riedl,
    • Katrin Schnizler,
    • Franz-Josef van der Staay,
    • Marja van Kampen,
    • Welf Burkhard Wiese,
    • and Gerhard Koenig

    The Novel α7 Nicotinic Acetylcholine Receptor Agonist N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide Improves Working and Recognition Memory in Rodents

    J Pharmacol Exp Ther May 2007 321:716-725; published ahead of print February 16, 2007, doi:10.1124/jpet.106.118976

Cover image

Cover image expansion

About the cover: Signaling microdomain identification in COS-1 cell plasma membrane. See the article by Mager and Abernethy on page 423 of this issue.

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This Issue

May 2007; 321 (2)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. ENDOCRINE AND DIABETES
  3. NEUROPHARMACOLOGY
  4. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  5. CARDIOVASCULAR
  6. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
  7. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  8. TOXICOLOGY
  9. CELLULAR AND MOLECULAR
  10. BEHAVIORAL PHARMACOLOGY

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