Table of Contents

May 2006; 317 (2)

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Clifford W. Mason,
    • Vanessa M. D'Souza,
    • Lisa M. Bareford,
    • Mitch A. Phelps,
    • Abhijit Ray,
    • and Peter W. Swaan

    Recognition, Cointernalization, and Recycling of an Avian Riboflavin Carrier Protein in Human Placental Trophoblasts

    J Pharmacol Exp Ther May 2006 317:465-472; published ahead of print January 6, 2006, doi:10.1124/jpet.105.096149
    • Sonia Mesia-Vela,
    • Rosa I. Sanchez,
    • Kenneth R. Reuhl,
    • Allan H. Conney,
    • and Frederick C. Kauffman

    Phenobarbital Treatment Inhibits the Formation of Estradiol-Dependent Mammary Tumors in the August-Copenhagen Irish Rat

    J Pharmacol Exp Ther May 2006 317:590-597; published ahead of print January 18, 2006, doi:10.1124/jpet.105.096867
    • P. R. Pentel,
    • M. B. Dufek,
    • S. A. Roiko,
    • M. G. LeSage,
    • and D. E. Keyler

    Differential Effects of Passive Immunization with Nicotine-Specific Antibodies on the Acute and Chronic Distribution of Nicotine to Brain in Rats

    J Pharmacol Exp Ther May 2006 317:660-666; published ahead of print January 11, 2006, doi:10.1124/jpet.105.097873
    • Haritha Mandula,
    • Jagan Mohan R. Parepally,
    • Rose Feng,
    • and Quentin R. Smith

    Role of Site-Specific Binding to Plasma Albumin in Drug Availability to Brain

    J Pharmacol Exp Ther May 2006 317:667-675; published ahead of print January 12, 2006, doi:10.1124/jpet.105.097402
    • Peng Hsiao,
    • Lucy Sasongko,
    • Jeanne M. Link,
    • David A. Mankoff,
    • Mark Muzi,
    • Ann C. Collier,
    • and Jashvant D. Unadkat

    Verapamil P-glycoprotein Transport across the Rat Blood-Brain Barrier: Cyclosporine, a Concentration Inhibition Analysis, and Comparison with Human Data

    J Pharmacol Exp Ther May 2006 317:704-710; published ahead of print January 13, 2006, doi:10.1124/jpet.105.097931
    • Mirco Govoni,
    • Simona Casagrande,
    • Raffaella Maucci,
    • Valerio Chiroli,
    • and Paola Tocchetti

    In Vitro Metabolism of (Nitrooxy)butyl Ester Nitric Oxide-Releasing Compounds: Comparison with Glyceryl Trinitrate

    J Pharmacol Exp Ther May 2006 317:752-761; published ahead of print January 19, 2006, doi:10.1124/jpet.105.097469
    • Kun Cheng,
    • Zhaoyang Ye,
    • Ramareddy V. Guntaka,
    • and Ram I. Mahato

    Enhanced Hepatic Uptake and Bioactivity of Type α1(I) Collagen Gene Promoter-Specific Triplex-Forming Oligonucleotides after Conjugation with Cholesterol

    J Pharmacol Exp Ther May 2006 317:797-805; published ahead of print February 1, 2006, doi:10.1124/jpet.105.100347
    • Hao-Jie Zhu,
    • Jun-Sheng Wang,
    • John S. Markowitz,
    • Jennifer L. Donovan,
    • Bryan B. Gibson,
    • Holly A. Gefroh,
    • and C. Lindsay DeVane

    Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

    J Pharmacol Exp Ther May 2006 317:850-857; published ahead of print January 26, 2006, doi:10.1124/jpet.105.098541
    • Margaret M. Doherty,
    • Karen Poon,
    • Carol Tsang,
    • and K. Sandy Pang

    Transport Is Not Rate-Limiting in Morphine Glucuronidation in the Single-Pass Perfused Rat Liver Preparation

    J Pharmacol Exp Ther May 2006 317:890-900; published ahead of print February 7, 2006, doi:10.1124/jpet.105.100446

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Almut Grenz,
    • Detlef Baier,
    • Fotios Petroktistis,
    • Manfred Wehrmann,
    • Christoph Köhle,
    • Martin Schenk,
    • Michael Sessler,
    • Christoph H. Gleiter,
    • Fred Fandrich,
    • and Hartmut Osswald

    Theophylline Improves Early Allograft Function in Rat Kidney Transplantation

    J Pharmacol Exp Ther May 2006 317:473-479; published ahead of print January 12, 2006, doi:10.1124/jpet.105.096917
    • Rick Greupink,
    • Hester I. Bakker,
    • Wilma Bouma,
    • Catharina Reker-Smit,
    • Dirk K. F. Meijer,
    • Leonie Beljaars,
    • and Klaas Poelstra

    The Antiproliferative Drug Doxorubicin Inhibits Liver Fibrosis in Bile Duct-Ligated Rats and Can Be Selectively Delivered to Hepatic Stellate Cells in Vivo

    J Pharmacol Exp Ther May 2006 317:514-521; published ahead of print January 26, 2006, doi:10.1124/jpet.105.099499
    • Carlos Medina,
    • Paul Jurasz,
    • Maria Jose Santos-Martinez,
    • Soon Seog Jeong,
    • Timothy Mitsky,
    • Ridong Chen,
    • and Marek W. Radomski

    Platelet Aggregation-Induced by Caco-2 Cells: Regulation by Matrix Metalloproteinase-2 and Adenosine Diphosphate

    J Pharmacol Exp Ther May 2006 317:739-745; published ahead of print January 19, 2006, doi:10.1124/jpet.105.098384
    • Cliff Battram,
    • Steven J. Charlton,
    • Bernard Cuenoud,
    • Mark R. Dowling,
    • Robin A. Fairhurst,
    • David Farr,
    • John R. Fozard,
    • Juliet R. Leighton-Davies,
    • Christine A. Lewis,
    • Lorraine McEvoy,
    • Robert J. Turner,
    • and Alexandre Trifilieff

    In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled β2 Adrenoceptor Agonist with a 24-h Duration of Action

    J Pharmacol Exp Ther May 2006 317:762-770; published ahead of print January 24, 2006, doi:10.1124/jpet.105.098251

NEUROPHARMACOLOGY

    • Norton H. Neff,
    • Trina A. Wemlinger,
    • Anne-Marie Duchemin,
    • and Maria Hadjiconstantinou

    Clozapine Modulates Aromatic l-Amino Acid Decarboxylase Activity in Mouse Striatum

    J Pharmacol Exp Ther May 2006 317:480-487; published ahead of print January 13, 2006, doi:10.1124/jpet.105.097972
    • Feng Han,
    • Yasufumi Shirasaki,
    • and Kohji Fukunaga

    3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin

    J Pharmacol Exp Ther May 2006 317:529-536; published ahead of print February 8, 2006, doi:10.1124/jpet.105.095018
    • Nobukazu Kakui,
    • Jiro Tanaka,
    • Yuji Tabata,
    • Kenji Asai,
    • Naomi Masuda,
    • Takako Miyara,
    • Yuko Nakatani,
    • Fukuichi Ohsawa,
    • Naoyuki Nishikawa,
    • Masaharu Sugai,
    • Makoto Suzuki,
    • Kozo Aoki,
    • and Hiroshi Kitaguchi

    Pharmacological Characterization and Feeding-Suppressive Property of FMS586 [3-(5,6,7,8-Tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea Hydrochloride], a Novel, Selective, and Orally Active Antagonist for Neuropeptide Y Y5 Receptor

    J Pharmacol Exp Ther May 2006 317:562-570; published ahead of print January 25, 2006, doi:10.1124/jpet.105.099705
    • Tangui Maurice,
    • Johann Meunier,
    • Bihua Feng,
    • John Ieni,
    • and Daniel T. Monaghan

    Interaction with σ1 Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

    J Pharmacol Exp Ther May 2006 317:606-614; published ahead of print January 5, 2006, doi:10.1124/jpet.105.097394
    • Anni-Maija Linden,
    • M. Isabel Aller,
    • Elli Leppä,
    • Olga Vekovischeva,
    • Teemu Aitta-aho,
    • Emma L. Veale,
    • Alistair Mathie,
    • Per Rosenberg,
    • William Wisden,
    • and Esa R. Korpi

    The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the α2 Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists

    J Pharmacol Exp Ther May 2006 317:615-626; published ahead of print January 5, 2006, doi:10.1124/jpet.105.098525
    • Anne M. Heacock,
    • Michael S. Dodd,
    • and Stephen K. Fisher

    Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors

    J Pharmacol Exp Ther May 2006 317:685-693; published ahead of print January 13, 2006, doi:10.1124/jpet.105.098467
    • Rafal M. Kaminski,
    • Herbert Marini,
    • Pavel I. Ortinski,
    • Stefano Vicini,
    • and Michael A. Rogawski

    The Pheromone Androstenol (5α-Androst-16-en-3α-ol) Is a Neurosteroid Positive Modulator of GABAA Receptors

    J Pharmacol Exp Ther May 2006 317:694-703; published ahead of print January 13, 2006, doi:10.1124/jpet.105.098319
    • J. E. Gibbs,
    • Z. Gaffen,
    • and S. A. Thomas

    Nevirapine Uptake into the Central Nervous System of the Guinea Pig: An in Situ Brain Perfusion Study

    J Pharmacol Exp Ther May 2006 317:746-751; published ahead of print January 19, 2006, doi:10.1124/jpet.105.098459
    • Jonathan D. Best,
    • Mark T. Jay,
    • Franklin Otu,
    • Ian Churcher,
    • Michael Reilly,
    • Pablo Morentin-Gutierrez,
    • Christine Pattison,
    • Tim Harrison,
    • Mark S. Shearman,
    • and John R. Atack

    In Vivo Characterization of Aβ(40) Changes in Brain and Cerebrospinal Fluid Using the Novel γ-Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the Rat

    J Pharmacol Exp Ther May 2006 317:786-790; published ahead of print January 27, 2006, doi:10.1124/jpet.105.100271
    • Brian J. Piper,
    • Huyen L. Vu,
    • Mina G. Safain,
    • Andrew J. Oliver,
    • and Jerrold S. Meyer

    Repeated Adolescent 3,4-Methylenedioxymethamphetamine (MDMA) Exposure in Rats Attenuates the Effects of a Subsequent Challenge with MDMA or a 5-Hydroxytryptamine1A Receptor Agonist

    J Pharmacol Exp Ther May 2006 317:838-849; published ahead of print January 24, 2006, doi:10.1124/jpet.105.095760
    • Yu Hasegawa,
    • Motohiro Morioka,
    • Shu Hasegawa,
    • Jun Matsumoto,
    • Takayuki Kawano,
    • Yutaka Kai,
    • Shigetoshi Yano,
    • Kohji Fukunaga,
    • and Jun-ichi Kuratsu

    Therapeutic Time Window and Dose Dependence of Neuroprotective Effects of Sodium Orthovanadate following Transient Middle Cerebral Artery Occlusion in Rats

    J Pharmacol Exp Ther May 2006 317:875-881; published ahead of print February 3, 2006, doi:10.1124/jpet.105.096677
    • Lei Tang,
    • Pradeep K. Shukla,
    • Lili X. Wang,
    • and Zaijie Jim Wang

    Reversal of Morphine Antinociceptive Tolerance and Dependence by the Acute Supraspinal Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase II

    J Pharmacol Exp Ther May 2006 317:901-909; published ahead of print February 27, 2006, doi:10.1124/jpet.105.097733
    • Kimberly E. Vanover,
    • David M. Weiner,
    • Malath Makhay,
    • Isaac Veinbergs,
    • Luis R. Gardell,
    • Jelveh Lameh,
    • Andria L. Del Tredici,
    • Fabrice Piu,
    • Hans H. Schiffer,
    • Thomas R. Ott,
    • Ethan S. Burstein,
    • Allan K. Uldam,
    • Mikkel B. Thygesen,
    • Nathalie Schlienger,
    • Carl Magnus Andersson,
    • Thomas Y. Son,
    • Scott C. Harvey,
    • Susan B. Powell,
    • Mark A. Geyer,
    • Bo-Ragner Tolf,
    • Mark R. Brann,
    • and Robert E. Davis

    Pharmacological and Behavioral Profile of N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl) Carbamide (2R,3R)-Dihydroxybutanedioate (2:1) (ACP-103), a Novel 5-Hydroxytryptamine2A Receptor Inverse Agonist

    J Pharmacol Exp Ther May 2006 317:910-918; published ahead of print February 9, 2006, doi:10.1124/jpet.105.097006

CARDIOVASCULAR

    • Lioubov I. Brueggemann,
    • Daniel R. Markun,
    • Kyle K. Henderson,
    • Leanne L. Cribbs,
    • and Kenneth L. Byron

    Pharmacological and Electrophysiological Characterization of Store-Operated Currents and Capacitative Ca2+ Entry in Vascular Smooth Muscle Cells

    J Pharmacol Exp Ther May 2006 317:488-499; published ahead of print January 13, 2006, doi:10.1124/jpet.105.095067
    • Nazareno Paolocci,
    • Barbara Tavazzi,
    • Roberto Biondi,
    • Yehezkiel A. Gluzband,
    • Angela Maria Amorini,
    • Carlo G. Tocchetti,
    • Mehrdad Hejazi,
    • Patrizio M. Caturegli,
    • Jan Kajstura,
    • Giuseppe Lazzarino,
    • and David A. Kass

    Metalloproteinase Inhibitor Counters High-Energy Phosphate Depletion and AMP Deaminase Activity Enhancing Ventricular Diastolic Compliance in Subacute Heart Failure

    J Pharmacol Exp Ther May 2006 317:506-513; published ahead of print January 25, 2006, doi:10.1124/jpet.105.099168
    • I. Tong Mak,
    • Joanna J. Chmielinska,
    • Lucie Nedelec,
    • Armida Torres,
    • and William B. Weglicki

    d-Propranolol Attenuates Lysosomal Iron Accumulation and Oxidative Injury in Endothelial Cells

    J Pharmacol Exp Ther May 2006 317:522-528; published ahead of print February 2, 2006, doi:10.1124/jpet.105.097709
    • Steve Xydas,
    • Aftab R. Kherani,
    • Jonathan S. Chang,
    • Stefan Klotz,
    • Ilan Hay,
    • Christopher J. Mutrie,
    • Garrett W. Moss,
    • Anguo Gu,
    • Allison R. Schulman,
    • Daqing Gao,
    • Debora Hu,
    • Ed X. Wu,
    • Chiming Wei,
    • Mehmet C. Oz,
    • and Jie Wang

    β2-Adrenergic Stimulation Attenuates Left Ventricular Remodeling, Decreases Apoptosis, and Improves Calcium Homeostasis in a Rodent Model of Ischemic Cardiomyopathy

    J Pharmacol Exp Ther May 2006 317:553-561; published ahead of print January 18, 2006, doi:10.1124/jpet.105.099432
    • Dong Ju Son,
    • Seong Jong Ha,
    • Ho Sueb Song,
    • Yong Lim,
    • Yeo Pyo Yun,
    • Jae Woong Lee,
    • Dong Cheul Moon,
    • Young Hyun Park,
    • Byeoung Soo Park,
    • Min Jong Song,
    • and Jin Tae Hong

    Melittin Inhibits Vascular Smooth Muscle Cell Proliferation through Induction of Apoptosis via Suppression of Nuclear Factor-κB and Akt Activation and Enhancement of Apoptotic Protein Expression

    J Pharmacol Exp Ther May 2006 317:627-634; published ahead of print January 9, 2006, doi:10.1124/jpet.105.095901
    • Courtney P. Judkins,
    • Christopher G. Sobey,
    • Thuy T. Dang,
    • Alyson A. Miller,
    • Gregory J. Dusting,
    • and Grant R. Drummond

    NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors

    J Pharmacol Exp Ther May 2006 317:644-650; published ahead of print January 11, 2006, doi:10.1124/jpet.105.096610
    • Peter Zahradka,
    • Brenda Wright,
    • Melissa Fuerst,
    • Natalia Yurkova,
    • Katerina Molnar,
    • and Carla G. Taylor

    Peroxisome Proliferator-Activated Receptor α and γ Ligands Differentially Affect Smooth Muscle Cell Proliferation and Migration

    J Pharmacol Exp Ther May 2006 317:651-659; published ahead of print January 11, 2006, doi:10.1124/jpet.105.096271
    • J. Callebert,
    • J. M. Esteve,
    • P. Hervé,
    • K. Peoc'h,
    • C. Tournois,
    • L. Drouet,
    • J. M. Launay,
    • and L. Maroteaux

    Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice

    J Pharmacol Exp Ther May 2006 317:724-731; published ahead of print February 3, 2006, doi:10.1124/jpet.105.098269
    • Zhigang Yu,
    • Valerie Y. Ng,
    • Ping Su,
    • Marguerite M. Engler,
    • Mary B. Engler,
    • Yong Huang,
    • Emil Lin,
    • and Deanna L. Kroetz

    Induction of Renal Cytochrome P450 Arachidonic Acid Epoxygenase Activity by Dietary γ-Linolenic Acid

    J Pharmacol Exp Ther May 2006 317:732-738; published ahead of print January 18, 2006, doi:10.1124/jpet.105.098558
    • Klaudia Budzyn,
    • Michelle Paull,
    • Philip D. Marley,
    • and Christopher G. Sobey

    Segmental Differences in the Roles of Rho-Kinase and Protein Kinase C in Mediating Vasoconstriction

    J Pharmacol Exp Ther May 2006 317:791-796; published ahead of print February 1, 2006, doi:10.1124/jpet.105.100040
    • Jae B. Park and
    • Norberta Schoene

    Clovamide-Type Phenylpropenoic Acid Amides, N-Coumaroyldopamine and N-Caffeoyldopamine, Inhibit Platelet-Leukocyte Interactions via Suppressing P-Selectin Expression

    J Pharmacol Exp Ther May 2006 317:813-819; published ahead of print February 14, 2006, doi:10.1124/jpet.105.097337
    • Carola Buccellati,
    • Angelo Sala,
    • Giuseppe Rossoni,
    • Valérie Capra,
    • G. Enrico Rovati,
    • Antonio Di Gennaro,
    • Giancarlo Folco,
    • Susanna Colli,
    • and Cesare Casagrande

    Pharmacological Characterization of 2NTX-99 [4-Methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a Potential Antiatherothrombotic Agent with Antithromboxane and Nitric Oxide Donor Activity in Platelet and Vascular Preparations

    J Pharmacol Exp Ther May 2006 317:830-837; published ahead of print January 6, 2006, doi:10.1124/jpet.105.097170
    • Jun Guo,
    • Hongying Gang,
    • and Shetuan Zhang

    Molecular Determinants of Cocaine Block of Human Ether-á-go-go-Related Gene Potassium Channels

    J Pharmacol Exp Ther May 2006 317:865-874; published ahead of print January 5, 2006, doi:10.1124/jpet.105.098103

CELLULAR AND MOLECULAR

    • Joanna Lipecka,
    • Caroline Norez,
    • Noura Bensalem,
    • Maryvonne Baudouin-Legros,
    • Gabrielle Planelles,
    • Frédéric Becq,
    • Aleksander Edelman,
    • and Noélie Davezac

    Rescue of ΔF508-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) by Curcumin: Involvement of the Keratin 18 Network

    J Pharmacol Exp Ther May 2006 317:500-505; published ahead of print January 19, 2006, doi:10.1124/jpet.105.097667
    • Xiao-Yan Chu,
    • John R. Strauss,
    • Michele A. Mariano,
    • Jing Li,
    • Deborah J. Newton,
    • Xiaoxin Cai,
    • Regina W. Wang,
    • Jocelyn Yabut,
    • Dylan P. Hartley,
    • David C. Evans,
    • and Raymond Evers

    Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)

    J Pharmacol Exp Ther May 2006 317:579-589; published ahead of print January 18, 2006, doi:10.1124/jpet.105.098665
    • Michael Saborowski,
    • Gerd A. Kullak-Ublick,
    • and Jyrki J. Eloranta

    The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α

    J Pharmacol Exp Ther May 2006 317:778-785; published ahead of print January 25, 2006, doi:10.1124/jpet.105.099929
    • Mary J. Clark,
    • Cheryse A. Furman,
    • Timra D. Gilson,
    • and John R. Traynor

    Comparison of the Relative Efficacy and Potency of μ-Opioid Agonists to Activate Gαi/o Proteins Containing a Pertussis Toxin-Insensitive Mutation

    J Pharmacol Exp Ther May 2006 317:858-864; published ahead of print January 25, 2006, doi:10.1124/jpet.105.096818

TOXICOLOGY

    • Jeffrey S. Moffit,
    • Lauren M. Aleksunes,
    • Jonathan M. Maher,
    • George L. Scheffer,
    • Curtis D. Klaassen,
    • and José E. Manautou

    Induction of Hepatic Transporters Multidrug Resistance-Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor α

    J Pharmacol Exp Ther May 2006 317:537-545; published ahead of print February 8, 2006, doi:10.1124/jpet.105.093765
    • James P. Luyendyk,
    • Lois D. Lehman-McKeeman,
    • David M. Nelson,
    • Vasanthi M. Bhaskaran,
    • Timothy P. Reilly,
    • Bruce D. Car,
    • Glenn H. Cantor,
    • Xiaomin Deng,
    • Jane F. Maddox,
    • Patricia E. Ganey,
    • and Robert A. Roth

    Coagulation-Dependent Gene Expression and Liver Injury in Rats Given Lipopolysaccharide with Ranitidine but Not with Famotidine

    J Pharmacol Exp Ther May 2006 317:635-643; published ahead of print January 9, 2006, doi:10.1124/jpet.105.096305

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Anna Martirosyan,
    • Stephen Leonard,
    • Xianglin Shi,
    • Brian Griffith,
    • Peter Gannett,
    • and Jeannine Strobl

    Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells

    J Pharmacol Exp Ther May 2006 317:546-552; published ahead of print February 23, 2006, doi:10.1124/jpet.105.096891

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Hoon-Suk Cha,
    • David L. Boyle,
    • Tomoyuki Inoue,
    • Reineke Schoot,
    • Paul P. Tak,
    • Polly Pine,
    • and Gary S. Firestein

    A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes

    J Pharmacol Exp Ther May 2006 317:571-578; published ahead of print February 1, 2006, doi:10.1124/jpet.105.097436
    • Hugh T. Abey,
    • David P. Fairlie,
    • James D. Moffatt,
    • Rowan W. Balzary,
    • and Thomas M. Cocks

    Protease-Activated Receptor-2 Peptides Activate Neurokinin-1 Receptors in the Mouse Isolated Trachea

    J Pharmacol Exp Ther May 2006 317:598-605; published ahead of print January 24, 2006, doi:10.1124/jpet.105.097121
    • Rowan W. Balzary and
    • Thomas M. Cocks

    Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2

    J Pharmacol Exp Ther May 2006 317:806-812; published ahead of print February 7, 2006, doi:10.1124/jpet.105.097634
    • Gautham K. Rao and
    • Norbert E. Kaminski

    Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship

    J Pharmacol Exp Ther May 2006 317:820-829; published ahead of print January 25, 2006, doi:10.1124/jpet.105.100503

ENDOCRINE AND DIABETES

    • Marjan Fatholahi,
    • Yiwen Xiang,
    • Yuzhi Wu,
    • Yuan Li,
    • Lin Wu,
    • Arvinder K. Dhalla,
    • Luiz Belardinelli,
    • and John C. Shryock

    A Novel Partial Agonist of the A1 -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes

    J Pharmacol Exp Ther May 2006 317:676-684; published ahead of print January 12, 2006, doi:10.1124/jpet.105.099119

BEHAVIORAL PHARMACOLOGY

    • S. Stevens Negus

    Choice between Heroin and Food in Nondependent and Heroin-Dependent Rhesus Monkeys: Effects of Naloxone, Buprenorphine, and Methadone

    J Pharmacol Exp Ther May 2006 317:711-723; published ahead of print February 2, 2006, doi:10.1124/jpet.105.095380
    • Janet R. Nicholson,
    • Götz Kohler,
    • Florian Schaerer,
    • Claudia Senn,
    • Philipp Weyermann,
    • and Karl G. Hofbauer

    Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice

    J Pharmacol Exp Ther May 2006 317:771-777; published ahead of print January 25, 2006, doi:10.1124/jpet.105.097725
    • Ian C. Webb,
    • Michael S. Pollock,
    • and Ralph E. Mistlberger

    Modafinil [2-[(Diphenylmethyl)sulfinyl]acetamide] and Circadian Rhythms in Syrian Hamsters: Assessment of the Chronobiotic Potential of a Novel Alerting Compound

    J Pharmacol Exp Ther May 2006 317:882-889; published ahead of print February 3, 2006, doi:10.1124/jpet.105.099010

Erratum

  • Correction to “Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Conditions: A Suggested Solution Based on in Vivo Occupancy”

    J Pharmacol Exp Ther May 2006 317:919

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About the cover: Clozapine increases AAAD mRNA in the mouse brain. See the article by Neff et al. on page 480 of this issue.

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May 2006; 317 (2)
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  1. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  2. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  3. NEUROPHARMACOLOGY
  4. CARDIOVASCULAR
  5. CELLULAR AND MOLECULAR
  6. TOXICOLOGY
  7. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  8. INFLAMMATION AND IMMUNOPHARMACOLOGY
  9. ENDOCRINE AND DIABETES
  10. BEHAVIORAL PHARMACOLOGY
  11. Erratum

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