Research ArticleCELLULAR AND MOLECULAR
Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice
Connie Cheung, Ai-Ming Yu, Chong-Sheng Chen, Kristopher W. Krausz, Linda G. Byrd, Lionel Feigenbaum, Robert J. Edwards, David J. Waxman and Frank J. Gonzalez
Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1328-1334; DOI: https://doi.org/10.1124/jpet.105.094367
Connie Cheung
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Ai-Ming Yu
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Chong-Sheng Chen
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Kristopher W. Krausz
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Linda G. Byrd
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Lionel Feigenbaum
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Robert J. Edwards
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
David J. Waxman
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
Frank J. Gonzalez
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.C., A.-M.Y., K.W.K., L.G.B., F.J.G); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (A.-M.Y.); Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts (C.-S.C., D.J.W.); Laboratory Animal Science Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland (L.F.); and Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, London, United Kingdom (R.J.E.)
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Research ArticleCELLULAR AND MOLECULAR
Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice
Connie Cheung, Ai-Ming Yu, Chong-Sheng Chen, Kristopher W. Krausz, Linda G. Byrd, Lionel Feigenbaum, Robert J. Edwards, David J. Waxman and Frank J. Gonzalez
Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1328-1334; DOI: https://doi.org/10.1124/jpet.105.094367
Research ArticleCELLULAR AND MOLECULAR
Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice
Connie Cheung, Ai-Ming Yu, Chong-Sheng Chen, Kristopher W. Krausz, Linda G. Byrd, Lionel Feigenbaum, Robert J. Edwards, David J. Waxman and Frank J. Gonzalez
Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1328-1334; DOI: https://doi.org/10.1124/jpet.105.094367
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